Ann Med Surg (Lond) . Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review

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Ann Med Surg (Lond)


. 2021 Oct 30;102988.
doi: 10.1016/j.amsu.2021.102988. Online ahead of print.
Vaccine-induced thrombotic thrombocytopenia following coronavirus vaccine: A narrative review


Syed Hassan Ahmed[SUP] 1 [/SUP], Taha Gul Shaikh[SUP] 1 [/SUP], Summaiyya Waseem[SUP] 1 [/SUP], Nashwa Abdul Qadir[SUP] 1 [/SUP], Zohaib Yousaf[SUP] 2 [/SUP], Irfan Ullah[SUP] 3 [/SUP]



Affiliations

• PMID: 34745596
• PMCID: PMC8556865
• DOI: 10.1016/j.amsu.2021.102988

Abstract

The novel coronavirus pandemic has taken a toll on the global healthcare systems and economy. Safety precautions, along with vaccination, are the most effective preventive measures. The global vaccination program against COVID-19 has dramatically reduced the number of deaths and cases. However, the incidence of thrombotic events and thrombocytopenia post-COVID-19 vaccination known as vaccine-induced thrombotic thrombocytopenia has raised safety concerns. This has led to an element of vaccine hesitancy. The exact mechanism for vaccine-induced thrombotic thrombocytopenia is unknown. Although the incidence of thrombosis associated with COVID-19 vaccination is low, it still requires attention, especially in older people, smokers, and people with preexisting comorbidities. This study aims to review the pathophysiology, diagnosis, and management of vaccine-induced thrombotic thrombocytopenia, to provide a concise and comprehensive update.

Keywords: COVID-19; COVID-19 vaccine; Thrombotic thrombocytopenia; VITT; Vaccine induced immune thrombotic thrombocytopenia; Vaccine induced thrombotic thrombocytopenia