tetano
Editor, Senior Moderator
Short communication
Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus
Ting Leia, b,
Kam-Leung Siub,
Kin-Hang Kokb,
Kwok-Hung Chanc,
Eric Y.T. Chand,
Ivan F.N. Hunge,
Kelvin K.W. Toc,
Patrick C.K. Lif,
Jie Zhouc,
Bo-Jian Zhengc,
Kwok-Yung Yuenc,
Ming Wangg,
Dong-Yan Jinb, Corresponding author contact information, E-mail the corresponding author
a Department of Pathology, School of Medicine, Xi′an Jiaotong University, Xi′an, China
b Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
c Department of Microbiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
d Department of Pathology, Queen Mary Hospital, Hong Kong, China
e Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
f Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China
g Guangzhou Center for Disease Control and Prevention, Guangzhou, China
Received 28 September 2011. Revised 2 February 2012. Accepted 3 February 2012. Available online 16 February 2012.
http://dx.doi.org/10.1016/j.vaccine.2012.02.009,
Abstract
Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barr? syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.
Highlights
► Recipients of 1976 H1N1 vaccine had an increased risk for neurologic disorder. ► Influenza hemagglutinin was reported to induce anti-ganglioside antibodies in mice. ► Absence of anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1 ► Absence of anti-ganglioside antibodies in eight confirmed cases of post-vaccination Guillain-Barr? syndrome.
http://www.sciencedirect.com/science/article/pii/S0264410X12001740
Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus
Ting Leia, b,
Kam-Leung Siub,
Kin-Hang Kokb,
Kwok-Hung Chanc,
Eric Y.T. Chand,
Ivan F.N. Hunge,
Kelvin K.W. Toc,
Patrick C.K. Lif,
Jie Zhouc,
Bo-Jian Zhengc,
Kwok-Yung Yuenc,
Ming Wangg,
Dong-Yan Jinb, Corresponding author contact information, E-mail the corresponding author
a Department of Pathology, School of Medicine, Xi′an Jiaotong University, Xi′an, China
b Department of Biochemistry, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
c Department of Microbiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
d Department of Pathology, Queen Mary Hospital, Hong Kong, China
e Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
f Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China
g Guangzhou Center for Disease Control and Prevention, Guangzhou, China
Received 28 September 2011. Revised 2 February 2012. Accepted 3 February 2012. Available online 16 February 2012.
http://dx.doi.org/10.1016/j.vaccine.2012.02.009,
Abstract
Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barr? syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.
Highlights
► Recipients of 1976 H1N1 vaccine had an increased risk for neurologic disorder. ► Influenza hemagglutinin was reported to induce anti-ganglioside antibodies in mice. ► Absence of anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1 ► Absence of anti-ganglioside antibodies in eight confirmed cases of post-vaccination Guillain-Barr? syndrome.
http://www.sciencedirect.com/science/article/pii/S0264410X12001740