tetano
Editor, Senior Moderator
Bioorg Med Chem. 2016 Aug 22. pii: S0968-0896(16)30644-7. doi: 10.1016/j.bmc.2016.08.037. [Epub ahead of print]
[h=1]Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes.[/h] Patrusheva OS[SUP]1[/SUP], Zarubaev VV[SUP]2[/SUP], Shtro AA[SUP]3[/SUP], Orshanskaya YR[SUP]3[/SUP], Boldyrev SA[SUP]3[/SUP], Ilyina IV[SUP]4[/SUP], Kurbakova SY[SUP]1[/SUP], Korchagina DV[SUP]1[/SUP], Volcho KP[SUP]4[/SUP], Salakhutdinov NF[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antiviral; Chromene; Influenza; Monoterpene
PMID: 27591012 DOI: 10.1016/j.bmc.2016.08.037
[PubMed - as supplied by publisher]
[h=1]Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes.[/h] Patrusheva OS[SUP]1[/SUP], Zarubaev VV[SUP]2[/SUP], Shtro AA[SUP]3[/SUP], Orshanskaya YR[SUP]3[/SUP], Boldyrev SA[SUP]3[/SUP], Ilyina IV[SUP]4[/SUP], Kurbakova SY[SUP]1[/SUP], Korchagina DV[SUP]1[/SUP], Volcho KP[SUP]4[/SUP], Salakhutdinov NF[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified.
Copyright ? 2016 Elsevier Ltd. All rights reserved.
[h=4]KEYWORDS:[/h] Antiviral; Chromene; Influenza; Monoterpene
PMID: 27591012 DOI: 10.1016/j.bmc.2016.08.037
[PubMed - as supplied by publisher]