Giuseppe
Emeritus
[Source: Archives of Neurology, full text: (LINK). Abstract, edited.]
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Observation| ONLINE FIRST
Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
ONLINE FIRST
David Y. Johnson, MD; Diana L. Dunkelberger, MA; Maya Henry, PhD; Aissatou Haman, MD; Michael D. Greicius, MD, PhD; Katherine Wong, BA; Stephen J. DeArmond, MD, PhD; Bruce L. Miller, MD; Maria Luisa Gorno-Tempini, MD, PhD; Michael D. Geschwind, MD, PhD
Arch Neurol. 2012;():1-4. doi:10.1001/jamaneurol.2013.139.
Published online November 5, 2012
ABSTRACT
Objective
To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.
Design
Case report.
Setting
Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.
Patient
Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.
Results
Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.
Conclusions
These findings expand the differential of primary progressive aphasia to include prion disease.
-Sporadic Jakob-Creutzfeldt Disease Presenting as Primary Progressive Aphasia
ONLINE FIRST
David Y. Johnson, MD; Diana L. Dunkelberger, MA; Maya Henry, PhD; Aissatou Haman, MD; Michael D. Greicius, MD, PhD; Katherine Wong, BA; Stephen J. DeArmond, MD, PhD; Bruce L. Miller, MD; Maria Luisa Gorno-Tempini, MD, PhD; Michael D. Geschwind, MD, PhD
Arch Neurol. 2012;():1-4. doi:10.1001/jamaneurol.2013.139.
Published online November 5, 2012
ABSTRACT
Objective
To report the clinical, neuropsychological, linguistic, imaging, and neuropathological features of a unique case of sporadic Jakob-Creutzfeldt disease in which the patient presented with a logopenic variant of primary progressive aphasia.
Design
Case report.
Setting
Large referral center for atypical memory and aging disorders, particularly Jakob-Creutzfeldt disease.
Patient
Patient presenting with logopenic variant primary progressive aphasia initially thought to be due to Alzheimer disease.
Results
Despite the long, slow 3.5-year course, the patient was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.
Conclusions
These findings expand the differential of primary progressive aphasia to include prion disease.
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