tetano
Editor, Senior Moderator
Arkh Patol
. 2020;82(5):57-62.
doi: 10.17116/patol20208205157.
[Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases)]
[Article in Russian]
E A Kogan[SUP] 1 [/SUP], Yu S Berezovsky[SUP] 2 [/SUP], A D Kukleva[SUP] 1 [/SUP], E V Kurilina[SUP] 3 [/SUP], L A Semenova[SUP] 2 [/SUP], O V Blagova[SUP] 1 [/SUP], N V Zharkov[SUP] 1 [/SUP]
Affiliations
Abstract
in English, Russian
The paper describes 4 autopsy cases of myocarditis in elderly patients with confirmed coronavirus infection. It gives the data of a morphological study of heart specimens and a detailed characterization of a myocardial infiltrate. An immunohistochemical study with cellular infiltrate typing was performed. The fact that lymphocytic viral myocarditis can develop in COVID-19 was morphologically and immunohistochemically confirmed. The features of myocarditis in COVID-19 are the development of the former in the presence of coronaritis and the possibility of its concurrence with lymphocytic endo- and pericarditis.
Keywords: ACE-2; CD3 T lymphocytes; COVID-19; SARS-CoV-2; TLR-4; TLR-9; coronavirus; endocarditis; myocarditis; perforin.
. 2020;82(5):57-62.
doi: 10.17116/patol20208205157.
[Lymphocytic myocarditis in patients with COVID-19 (4 autopsy cases)]
[Article in Russian]
E A Kogan[SUP] 1 [/SUP], Yu S Berezovsky[SUP] 2 [/SUP], A D Kukleva[SUP] 1 [/SUP], E V Kurilina[SUP] 3 [/SUP], L A Semenova[SUP] 2 [/SUP], O V Blagova[SUP] 1 [/SUP], N V Zharkov[SUP] 1 [/SUP]
Affiliations
- PMID: 33054033
- DOI: 10.17116/patol20208205157
Abstract
in English, Russian
The paper describes 4 autopsy cases of myocarditis in elderly patients with confirmed coronavirus infection. It gives the data of a morphological study of heart specimens and a detailed characterization of a myocardial infiltrate. An immunohistochemical study with cellular infiltrate typing was performed. The fact that lymphocytic viral myocarditis can develop in COVID-19 was morphologically and immunohistochemically confirmed. The features of myocarditis in COVID-19 are the development of the former in the presence of coronaritis and the possibility of its concurrence with lymphocytic endo- and pericarditis.
Keywords: ACE-2; CD3 T lymphocytes; COVID-19; SARS-CoV-2; TLR-4; TLR-9; coronavirus; endocarditis; myocarditis; perforin.