tetano
Editor, Senior Moderator
Biochimie
. 2020 May 29;S0300-9084(20)30128-0.
doi: 10.1016/j.biochi.2020.05.012. Online ahead of print.
SARS-CoV-2 Entry in Host Cells-Multiple Targets for Treatment and Prevention
Ismail Sami Mahmoud[SUP] 1 [/SUP], Yazun Bashir Jarrar[SUP] 2 [/SUP], Walhan Alshaer[SUP] 3 [/SUP], Said Ismail[SUP] 4 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.
Keywords: ACE2; Drugs; Entry; Proteases; SARS-CoV-2.
. 2020 May 29;S0300-9084(20)30128-0.
doi: 10.1016/j.biochi.2020.05.012. Online ahead of print.
SARS-CoV-2 Entry in Host Cells-Multiple Targets for Treatment and Prevention
Ismail Sami Mahmoud[SUP] 1 [/SUP], Yazun Bashir Jarrar[SUP] 2 [/SUP], Walhan Alshaer[SUP] 3 [/SUP], Said Ismail[SUP] 4 [/SUP]
Affiliations
- PMID: 32479856
- DOI: 10.1016/j.biochi.2020.05.012
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new viral disease that has gained global attention owing to its ability to provoke community and health-care-associated outbreaks of severe infections in human populations. The virus poses serious challenges to clinical management because there are still no approved anti- SARS-CoV-2 drugs available. In this mini-review, we summarize the much updated published reports that demonstrate the mechanism of SARS-CoV-2 entry into host cells, and discuss the availability and development of attractive host-based therapeutic options for SARS-CoV-2 infections.
Keywords: ACE2; Drugs; Entry; Proteases; SARS-CoV-2.