tetano
Editor, Senior Moderator
Biomolecules
. 2021 May 6;11(5):694.
doi: 10.3390/biom11050694.
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
Brandon Bautista-Becerril[SUP] 1 2 [/SUP], Rebeca Campi-Caballero[SUP] 2 3 [/SUP], Samuel Sevilla-Fuentes[SUP] 4 [/SUP], Laura M Hernández-Regino[SUP] 5 [/SUP], Alejandro Hanono[SUP] 6 [/SUP], Al Flores-Bustamante[SUP] 7 [/SUP], Julieta González-Flores[SUP] 2 [/SUP], Carlos A García-Ávila[SUP] 5 [/SUP], Arnoldo Aquino-Gálvez[SUP] 8 [/SUP], Manuel Castillejos-López[SUP] 9 [/SUP], Armida Juárez-Cisneros[SUP] 1 [/SUP], Angel Camarena[SUP] 1 [/SUP]
Affiliations
Abstract
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.
Keywords: CID; COVID-19; SARS-CoV-2; immunothrombosis; neutrophil extracellular traps.
. 2021 May 6;11(5):694.
doi: 10.3390/biom11050694.
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps
Brandon Bautista-Becerril[SUP] 1 2 [/SUP], Rebeca Campi-Caballero[SUP] 2 3 [/SUP], Samuel Sevilla-Fuentes[SUP] 4 [/SUP], Laura M Hernández-Regino[SUP] 5 [/SUP], Alejandro Hanono[SUP] 6 [/SUP], Al Flores-Bustamante[SUP] 7 [/SUP], Julieta González-Flores[SUP] 2 [/SUP], Carlos A García-Ávila[SUP] 5 [/SUP], Arnoldo Aquino-Gálvez[SUP] 8 [/SUP], Manuel Castillejos-López[SUP] 9 [/SUP], Armida Juárez-Cisneros[SUP] 1 [/SUP], Angel Camarena[SUP] 1 [/SUP]
Affiliations
- PMID: 34066385
- DOI: 10.3390/biom11050694
Abstract
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.
Keywords: CID; COVID-19; SARS-CoV-2; immunothrombosis; neutrophil extracellular traps.