tetano
Editor, Senior Moderator
Blood Cells Mol Dis
. 2023 Apr 28;102746.
doi: 10.1016/j.bcmd.2023.102746. Online ahead of print. γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Lucy Z Kornblith[SUP] 1 [/SUP], Bindhya Sadhanandhan[SUP] 2 [/SUP], Sreepriya Arun[SUP] 2 [/SUP], Rebecca Long[SUP] 3 [/SUP], Alicia J Johnson[SUP] 4 [/SUP], Jamie Noll[SUP] 5 [/SUP], C N Ramchand[SUP] 6 [/SUP], John K Olynyk[SUP] 7 [/SUP], David H Farrell[SUP] 8 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO[SUB]2[/SUB]). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95 % CI 64.8-74.8) mg/dL compared with 36.9 (95 % CI 31.4-42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO[SUB]2[/SUB] ≤ 93 %, GPF 75.2 (95 % CI 68.7-81.8) mg/dL), compared to mild/moderate COVID-19 (SpO[SUB]2[/SUB] > 93 %, GPF 62.5 (95 % CI 55.0-70.0) mg/dL, p = 0.01, AUC of 0.68, 95 % CI 0.57-0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
Keywords: Biomarkers; COVID-19; Disease progression; Fibrinogen; Respiratory distress syndrome.
. 2023 Apr 28;102746.
doi: 10.1016/j.bcmd.2023.102746. Online ahead of print. γ' fibrinogen levels as a biomarker of COVID-19 respiratory disease severity
Lucy Z Kornblith[SUP] 1 [/SUP], Bindhya Sadhanandhan[SUP] 2 [/SUP], Sreepriya Arun[SUP] 2 [/SUP], Rebecca Long[SUP] 3 [/SUP], Alicia J Johnson[SUP] 4 [/SUP], Jamie Noll[SUP] 5 [/SUP], C N Ramchand[SUP] 6 [/SUP], John K Olynyk[SUP] 7 [/SUP], David H Farrell[SUP] 8 [/SUP]
Affiliations
- PMID: 37150704
- DOI: 10.1016/j.bcmd.2023.102746
Coronavirus disease 2019 (COVID-19) is characterized by a pro-inflammatory state associated with organ failure, thrombosis, and death. We investigated a novel inflammatory biomarker, γ' fibrinogen (GPF), in 103 hospitalized patients with COVID-19 and 19 healthy controls. We found significant associations between GPF levels and the severity of COVID-19 as judged by blood oxygen saturation (SpO[SUB]2[/SUB]). The mean level of GPF in the patients with COVID-19 was significantly higher than in controls (69.8 (95 % CI 64.8-74.8) mg/dL compared with 36.9 (95 % CI 31.4-42.4) mg/dL, p < 0.0001), whereas C-reactive protein (CRP), lactate dehydrogenase (LDH), and total fibrinogen levels were not significantly different between groups. Mean GPF levels were significantly highest in patients with severe COVID-19 (SpO[SUB]2[/SUB] ≤ 93 %, GPF 75.2 (95 % CI 68.7-81.8) mg/dL), compared to mild/moderate COVID-19 (SpO[SUB]2[/SUB] > 93 %, GPF 62.5 (95 % CI 55.0-70.0) mg/dL, p = 0.01, AUC of 0.68, 95 % CI 0.57-0.78; Youden's index cutpoint 62.9 mg/dL, sensitivity 0.64, specificity 0.63). In contrast, CRP, interleukin-6, ferritin, LDH, D-dimers, and total fibrinogen had weaker associations with COVID-19 disease severity (all ROC curves with lower AUCs). Thus, GPF may be a useful inflammatory marker of COVID-19 respiratory disease severity.
Keywords: Biomarkers; COVID-19; Disease progression; Fibrinogen; Respiratory distress syndrome.