tetano
Editor, Senior Moderator
BMC Cardiovasc Disord
. 2023 Aug 8;23(1):389.
doi: 10.1186/s12872-023-03412-7. Post-COVID-19 illness and associations with sex and gender
Kenneth Mangion[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 3 4 [/SUP], Robert Sykes[SUP] 3 4 [/SUP], Anna Kamdar[SUP] 3 [/SUP], Catherine Bagot[SUP] 5 [/SUP], George Bruce[SUP] 6 [/SUP], Paul Connelly[SUP] 3 [/SUP], Christian Delles[SUP] 3 [/SUP], Vivienne B Gibson[SUP] 5 [/SUP], Lynsey Gillespie[SUP] 7 [/SUP], Pauline Hall Barrientos[SUP] 6 [/SUP], Vera Lennie[SUP] 8 [/SUP], Giles Roditi[SUP] 9 [/SUP], Naveed Sattar[SUP] 3 [/SUP], David Stobo[SUP] 9 [/SUP], Sarah Allwood-Spiers[SUP] 6 [/SUP], Alex McConnachie[SUP] 10 [/SUP], Colin Berry[SUP] 3 4 [/SUP]; CISCO-19 investigators
Collaborators, Affiliations
Background: Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.
Aim: There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.
Design: This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence.
Methods: Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28-60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization.
Results: Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28-60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018).
Conclusions: Women demonstrated worse patient reported outcome measures at index admission and 28-60 days follow-up though cardiovascular hospitalization was lower.
Keywords: COVID-19; Female sex; Male sex; Myocardial inflammation; Myocarditis; Post-COVID-19 syndrome; SARS CoV-2; Severe acute respiratory syndrome coronavirus-19.
. 2023 Aug 8;23(1):389.
doi: 10.1186/s12872-023-03412-7. Post-COVID-19 illness and associations with sex and gender
Kenneth Mangion[SUP] 1 2 [/SUP], Andrew J Morrow[SUP] 3 4 [/SUP], Robert Sykes[SUP] 3 4 [/SUP], Anna Kamdar[SUP] 3 [/SUP], Catherine Bagot[SUP] 5 [/SUP], George Bruce[SUP] 6 [/SUP], Paul Connelly[SUP] 3 [/SUP], Christian Delles[SUP] 3 [/SUP], Vivienne B Gibson[SUP] 5 [/SUP], Lynsey Gillespie[SUP] 7 [/SUP], Pauline Hall Barrientos[SUP] 6 [/SUP], Vera Lennie[SUP] 8 [/SUP], Giles Roditi[SUP] 9 [/SUP], Naveed Sattar[SUP] 3 [/SUP], David Stobo[SUP] 9 [/SUP], Sarah Allwood-Spiers[SUP] 6 [/SUP], Alex McConnachie[SUP] 10 [/SUP], Colin Berry[SUP] 3 4 [/SUP]; CISCO-19 investigators
Collaborators, Affiliations
- PMID: 37553628
- DOI: 10.1186/s12872-023-03412-7
Background: Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.
Aim: There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) in post-COVID-19 patients, and in patient reported health outcomes following COVID-19 infection.
Design: This prospective study investigated the time-course of multiorgan injury in survivors of COVID-19 during convalescence.
Methods: Clinical information, blood biomarkers, and patient reported outcome measures were prospectively acquired at enrolment (visit 1) and 28-60 days post-discharge (visit 2). Chest computed tomography (CT) and CMR were performed at visit 2. Follow-up was carried out for serious adverse events, including death and rehospitalization.
Results: Sixty-nine (43%) of 159 patients recruited were female. During the index admission, females had a lower peak C-reactive protein (74 mg/l (21,163) versus 123 mg/l (70, 192) p = 0.008) and peak ferritin (229 μg/l (103, 551) versus 514 μg/l (228, 1122) p < 0.001). Using the Modified Lake-Louise criteria, females were more likely to have definite evidence of myocardial inflammation (54% (37/68) versus 33% (30/90) p = 0.003). At enrolment and 28-60 days post-discharge, enhanced illness perception, higher levels of anxiety and depression and lower predicted maximal oxygen utilization occurred more commonly in women. The mean (SD, range) duration of follow-up after hospital discharge was 450 (88) days (range 290, 627 days). Compared to men, women had lower rates of cardiovascular hospitalization (0% versus 8% (7/90); p = 0.018).
Conclusions: Women demonstrated worse patient reported outcome measures at index admission and 28-60 days follow-up though cardiovascular hospitalization was lower.
Keywords: COVID-19; Female sex; Male sex; Myocardial inflammation; Myocarditis; Post-COVID-19 syndrome; SARS CoV-2; Severe acute respiratory syndrome coronavirus-19.