tetano
Editor, Senior Moderator
BMC Genom Data
. 2023 Jun 21;24(1):34.
doi: 10.1186/s12863-023-01133-6. Association between SUMF1 polymorphisms and COVID-19 severity
Shaohui Liang[SUP] #[/SUP][SUP] 1 [/SUP], Huixia Gao[SUP] #[/SUP][SUP] 2 [/SUP], Tongxin He[SUP] #[/SUP][SUP] 3 [/SUP], Li Li[SUP] 4 [/SUP], Xin Zhang[SUP] 5 [/SUP], Lei Zhao[SUP] 6 [/SUP], Jie Chen[SUP] 7 [/SUP], Yanyan Xie[SUP] 7 [/SUP], Jie Bao[SUP] 1 [/SUP], Yong Gao[SUP] 1 [/SUP], Erhei Dai[SUP] 8 [/SUP], Yuling Wang[SUP] 9 10 [/SUP]
Affiliations
Background: Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.
Results: We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).
Conclusions: In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.
Keywords: COVID-19; Multiple sclerosis; SUMF1; rs794185.
. 2023 Jun 21;24(1):34.
doi: 10.1186/s12863-023-01133-6. Association between SUMF1 polymorphisms and COVID-19 severity
Shaohui Liang[SUP] #[/SUP][SUP] 1 [/SUP], Huixia Gao[SUP] #[/SUP][SUP] 2 [/SUP], Tongxin He[SUP] #[/SUP][SUP] 3 [/SUP], Li Li[SUP] 4 [/SUP], Xin Zhang[SUP] 5 [/SUP], Lei Zhao[SUP] 6 [/SUP], Jie Chen[SUP] 7 [/SUP], Yanyan Xie[SUP] 7 [/SUP], Jie Bao[SUP] 1 [/SUP], Yong Gao[SUP] 1 [/SUP], Erhei Dai[SUP] 8 [/SUP], Yuling Wang[SUP] 9 10 [/SUP]
Affiliations
- PMID: 37344788
- DOI: 10.1186/s12863-023-01133-6
Background: Evidence shows that genetic factors play important roles in the severity of coronavirus disease 2019 (COVID-19). Sulfatase modifying factor 1 (SUMF1) gene is involved in alveolar damage and systemic inflammatory response. Therefore, we speculate that it may play a key role in COVID-19.
Results: We found that rs794185 was significantly associated with COVID-19 severity in Chinese population, under the additive model after adjusting for gender and age (for C allele = 0.62, 95% CI = 0.44-0.88, P = 0.0073, logistic regression). And this association was consistent with this in European population Genetics Of Mortality In Critical Care (GenOMICC: OR for C allele = 0.94, 95% CI = 0.90-0.98, P = 0.0037). Additionally, we also revealed a remarkable association between rs794185 and the prothrombin activity (PTA) in subjects (P = 0.015, Generalized Linear Model).
Conclusions: In conclusion, our study for the first time identified that rs794185 in SUMF1 gene was associated with the severity of COVID-19.
Keywords: COVID-19; Multiple sclerosis; SUMF1; rs794185.