tetano
Editor, Senior Moderator
BMC Immunol
. 2024 Jun 28;25(1):38.
doi: 10.1186/s12865-024-00631-1. The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population
Narges Karami[SUP] 1 [/SUP], Shaghik Barani[SUP] 1 2 [/SUP], Mona Fani[SUP] 3 [/SUP], Seppo Meri[SUP] 4 [/SUP], Reza Shafiei[SUP] 5 [/SUP], Kurosh Kalantar[SUP] 6 7 8 [/SUP]
Affiliations
Background: Variations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell (NK) function is regulated by sophisticated receptor system including Killer-cell immunoglobulin-like receptor (KIR) family. We aimed to investigate the impact of possessing certain KIR genes and genotypes on COVID19 severity in Iranians. KIR genotyping was performed on 394 age/sex matched Iranians with no underlying conditions who developed mild and severe COVID- 19. The presence and/or absence of 11 KIR genes were determined using the PCR with sequence specific primers (PCR-SSP).
Results: Patients with mild symptoms had higher frequency ofKIR2DS1 (p = 0.004) and KIR2DS2 (p = 0.017) genes compared to those with severe disease. While KIR3DL3 and deleted variant of KIR2DS4 occurred more frequently in patients who developed a severe form of the disease. In this study, a significant increase of and B haplotype was observed in the Mild group compared to the Severe group (respectively, p = 0.002 and p = 0.02). Also, the prevalence of haplotype A was significantly higher in the Severe group than in the Mild group (p = 0.02).
Conclusions: These results suggest that the KIR2DS1, KIR2DS, and B haplotype maybe have a protective effect against COVID-19 severity. The results also suggest the inhibitory gene KIR2DL3 and haplotype A are risk factors for the severity of COVID-19.
Keywords: COVID-19; Killer cell immunoglobulin-like receptors (KIRs); NK cell.
. 2024 Jun 28;25(1):38.
doi: 10.1186/s12865-024-00631-1. The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population
Narges Karami[SUP] 1 [/SUP], Shaghik Barani[SUP] 1 2 [/SUP], Mona Fani[SUP] 3 [/SUP], Seppo Meri[SUP] 4 [/SUP], Reza Shafiei[SUP] 5 [/SUP], Kurosh Kalantar[SUP] 6 7 8 [/SUP]
Affiliations
- PMID: 38943065
- PMCID: PMC11212229
- DOI: 10.1186/s12865-024-00631-1
Background: Variations in the innate and adaptive immune response systems are linked to variations in the severity of COVID-19. Natural killer cell (NK) function is regulated by sophisticated receptor system including Killer-cell immunoglobulin-like receptor (KIR) family. We aimed to investigate the impact of possessing certain KIR genes and genotypes on COVID19 severity in Iranians. KIR genotyping was performed on 394 age/sex matched Iranians with no underlying conditions who developed mild and severe COVID- 19. The presence and/or absence of 11 KIR genes were determined using the PCR with sequence specific primers (PCR-SSP).
Results: Patients with mild symptoms had higher frequency ofKIR2DS1 (p = 0.004) and KIR2DS2 (p = 0.017) genes compared to those with severe disease. While KIR3DL3 and deleted variant of KIR2DS4 occurred more frequently in patients who developed a severe form of the disease. In this study, a significant increase of and B haplotype was observed in the Mild group compared to the Severe group (respectively, p = 0.002 and p = 0.02). Also, the prevalence of haplotype A was significantly higher in the Severe group than in the Mild group (p = 0.02).
Conclusions: These results suggest that the KIR2DS1, KIR2DS, and B haplotype maybe have a protective effect against COVID-19 severity. The results also suggest the inhibitory gene KIR2DL3 and haplotype A are risk factors for the severity of COVID-19.
Keywords: COVID-19; Killer cell immunoglobulin-like receptors (KIRs); NK cell.