tetano
Editor, Senior Moderator
BMC Infect Dis
. 2023 Dec 20;23(1):895.
doi: 10.1186/s12879-023-08465-9. The value of serum neutralizing antibody in evaluating predictability of COVID-19 after recovery and the validation of vaccine
Bianqin Guo[SUP] #[/SUP][SUP] 1 [/SUP], Zheng Li[SUP] #[/SUP][SUP] 1 [/SUP], Gang Fu[SUP] #[/SUP][SUP] 1 [/SUP], Hong Li[SUP] 1 [/SUP], Jing Yang[SUP] 1 [/SUP], Zhenbin Zhang[SUP] 2 [/SUP], Lixiang Wu[SUP] 3 [/SUP], Jing Wang[SUP] 4 [/SUP]
Affiliations
Background: This work aimed to study natural humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: Chemiluminescent immunoassay (CLIA) was used to detect the neutralizing antibody (Nabs) and IgG.
Results: Nabs peaked on days 57-96 after symptom onset and remained detected on days 97-132. The Nabs in the 32 patients who were dynamically monitored showed four changing patterns. The titers of Nabs and IgG were correlated, and three modes of relationship were found between them.
Conclusions: Nabs showed a regular change in the course of coronavirus disease 2019 (COVID-19). The detection of Nabs is very important for monitoring the course of COVID-19 and predicting the strength of antibody protection.
Keywords: COVID-19; IgG; Neutralizing antibody; SARS‐CoV‐2.
. 2023 Dec 20;23(1):895.
doi: 10.1186/s12879-023-08465-9. The value of serum neutralizing antibody in evaluating predictability of COVID-19 after recovery and the validation of vaccine
Bianqin Guo[SUP] #[/SUP][SUP] 1 [/SUP], Zheng Li[SUP] #[/SUP][SUP] 1 [/SUP], Gang Fu[SUP] #[/SUP][SUP] 1 [/SUP], Hong Li[SUP] 1 [/SUP], Jing Yang[SUP] 1 [/SUP], Zhenbin Zhang[SUP] 2 [/SUP], Lixiang Wu[SUP] 3 [/SUP], Jing Wang[SUP] 4 [/SUP]
Affiliations
- PMID: 38124038
- DOI: 10.1186/s12879-023-08465-9
Background: This work aimed to study natural humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: Chemiluminescent immunoassay (CLIA) was used to detect the neutralizing antibody (Nabs) and IgG.
Results: Nabs peaked on days 57-96 after symptom onset and remained detected on days 97-132. The Nabs in the 32 patients who were dynamically monitored showed four changing patterns. The titers of Nabs and IgG were correlated, and three modes of relationship were found between them.
Conclusions: Nabs showed a regular change in the course of coronavirus disease 2019 (COVID-19). The detection of Nabs is very important for monitoring the course of COVID-19 and predicting the strength of antibody protection.
Keywords: COVID-19; IgG; Neutralizing antibody; SARS‐CoV‐2.