tetano
Editor, Senior Moderator
BMC Med
. 2023 Oct 13;21(1):390.
doi: 10.1186/s12916-023-03079-z. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Sangeetha Shyam[SUP] 1 2 3 [/SUP], Jesús Francisco García-Gavilán[SUP] 4 5 6 [/SUP], Indira Paz-Graniel[SUP] 4 5 6 [/SUP], José J Gaforio[SUP] 7 8 [/SUP], Miguel Ángel Martínez-González[SUP] 4 9 10 [/SUP], Dolores Corella[SUP] 4 11 [/SUP], J Alfredo Martínez[SUP] 4 12 13 14 [/SUP], Ángel M Alonso-Gómez[SUP] 4 15 [/SUP], Julia Wärnberg[SUP] 4 16 [/SUP], Jesús Vioque[SUP] 7 17 [/SUP], Dora Romaguera[SUP] 4 18 [/SUP], José López-Miranda[SUP] 4 19 [/SUP], Ramon Estruch[SUP] 4 20 21 [/SUP], Francisco J Tinahones[SUP] 4 22 [/SUP], José Lapetra[SUP] 4 23 [/SUP], J Luís Serra-Majem[SUP] 4 24 [/SUP], Aurora Bueno-Cavanillas[SUP] 7 25 [/SUP], Josep A Tur[SUP] 4 26 [/SUP], Vicente Martín Sánchez[SUP] 7 27 [/SUP], Xavier Pintó[SUP] 4 28 [/SUP], Pilar Matía-Martín[SUP] 29 30 [/SUP], Josep Vidal[SUP] 31 32 [/SUP], Clotilde Vázquez[SUP] 4 33 [/SUP], Lidia Daimiel[SUP] 4 34 35 [/SUP], Emilio Ros[SUP] 4 36 [/SUP], Fernando Fernandez-Aranda[SUP] 4 37 38 [/SUP], Stephanie K Nishi[SUP] 4 5 6 39 [/SUP], Oscar Garcia-Regata[SUP] 15 [/SUP], Estefania Toledo[SUP] 4 9 [/SUP], Eva M Asensio[SUP] 4 11 [/SUP], Olga Castañer[SUP] 7 40 [/SUP], Antonio Garcia-Rios[SUP] 4 19 [/SUP], Laura Torres-Collado[SUP] 7 17 [/SUP], Enrique Gómez-Gracia[SUP] 41 [/SUP], M Angeles Zulet[SUP] 4 12 [/SUP], Nuria Goñi Ruiz[SUP] 42 43 44 [/SUP], Rosa Casas[SUP] 4 20 21 [/SUP], Naomi Cano-Ibáñez[SUP] 7 25 45 [/SUP], Lucas Tojal-Sierra[SUP] 4 15 [/SUP], A M Gómez-Perez[SUP] 4 22 [/SUP], Jose V Sorlí[SUP] 4 11 [/SUP], Sergio Cinza-Sanjurjo[SUP] 46 47 48 [/SUP], Sandra Martín-Peláez[SUP] 7 25 [/SUP], Patricia J Peña-Orihuela[SUP] 4 19 [/SUP], Alejandro Oncina-Canovas[SUP] 7 17 [/SUP], Rafael Perez-Araluce[SUP] 9 [/SUP], María Dolores Zomeño[SUP] 4 40 49 [/SUP], Alice Chaplin[SUP] 4 18 [/SUP], Miguel Delgado-Rodríguez[SUP] 4 13 14 50 [/SUP], Nancy Babio[SUP] 4 5 6 [/SUP], Montserrat Fitó[SUP] #[/SUP][SUP] 4 40 [/SUP], Jordi Salas-Salvadó[SUP] #[/SUP][SUP] 51 52 53 [/SUP]
Affiliations
Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.
Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.
Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HR[SUB]adj[/SUB] (95%CI): 1.01 (1.00, 1.03)) and BMI (HR[SUB]adj[/SUB]: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.
Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.
Trial registration: This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).
Keywords: COVID-19; Central obesity; Obesity; Older adults; Weight loss.
. 2023 Oct 13;21(1):390.
doi: 10.1186/s12916-023-03079-z. Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort
Sangeetha Shyam[SUP] 1 2 3 [/SUP], Jesús Francisco García-Gavilán[SUP] 4 5 6 [/SUP], Indira Paz-Graniel[SUP] 4 5 6 [/SUP], José J Gaforio[SUP] 7 8 [/SUP], Miguel Ángel Martínez-González[SUP] 4 9 10 [/SUP], Dolores Corella[SUP] 4 11 [/SUP], J Alfredo Martínez[SUP] 4 12 13 14 [/SUP], Ángel M Alonso-Gómez[SUP] 4 15 [/SUP], Julia Wärnberg[SUP] 4 16 [/SUP], Jesús Vioque[SUP] 7 17 [/SUP], Dora Romaguera[SUP] 4 18 [/SUP], José López-Miranda[SUP] 4 19 [/SUP], Ramon Estruch[SUP] 4 20 21 [/SUP], Francisco J Tinahones[SUP] 4 22 [/SUP], José Lapetra[SUP] 4 23 [/SUP], J Luís Serra-Majem[SUP] 4 24 [/SUP], Aurora Bueno-Cavanillas[SUP] 7 25 [/SUP], Josep A Tur[SUP] 4 26 [/SUP], Vicente Martín Sánchez[SUP] 7 27 [/SUP], Xavier Pintó[SUP] 4 28 [/SUP], Pilar Matía-Martín[SUP] 29 30 [/SUP], Josep Vidal[SUP] 31 32 [/SUP], Clotilde Vázquez[SUP] 4 33 [/SUP], Lidia Daimiel[SUP] 4 34 35 [/SUP], Emilio Ros[SUP] 4 36 [/SUP], Fernando Fernandez-Aranda[SUP] 4 37 38 [/SUP], Stephanie K Nishi[SUP] 4 5 6 39 [/SUP], Oscar Garcia-Regata[SUP] 15 [/SUP], Estefania Toledo[SUP] 4 9 [/SUP], Eva M Asensio[SUP] 4 11 [/SUP], Olga Castañer[SUP] 7 40 [/SUP], Antonio Garcia-Rios[SUP] 4 19 [/SUP], Laura Torres-Collado[SUP] 7 17 [/SUP], Enrique Gómez-Gracia[SUP] 41 [/SUP], M Angeles Zulet[SUP] 4 12 [/SUP], Nuria Goñi Ruiz[SUP] 42 43 44 [/SUP], Rosa Casas[SUP] 4 20 21 [/SUP], Naomi Cano-Ibáñez[SUP] 7 25 45 [/SUP], Lucas Tojal-Sierra[SUP] 4 15 [/SUP], A M Gómez-Perez[SUP] 4 22 [/SUP], Jose V Sorlí[SUP] 4 11 [/SUP], Sergio Cinza-Sanjurjo[SUP] 46 47 48 [/SUP], Sandra Martín-Peláez[SUP] 7 25 [/SUP], Patricia J Peña-Orihuela[SUP] 4 19 [/SUP], Alejandro Oncina-Canovas[SUP] 7 17 [/SUP], Rafael Perez-Araluce[SUP] 9 [/SUP], María Dolores Zomeño[SUP] 4 40 49 [/SUP], Alice Chaplin[SUP] 4 18 [/SUP], Miguel Delgado-Rodríguez[SUP] 4 13 14 50 [/SUP], Nancy Babio[SUP] 4 5 6 [/SUP], Montserrat Fitó[SUP] #[/SUP][SUP] 4 40 [/SUP], Jordi Salas-Salvadó[SUP] #[/SUP][SUP] 51 52 53 [/SUP]
Affiliations
- PMID: 37833678
- PMCID: PMC10576302
- DOI: 10.1186/s12916-023-03079-z
Background: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.
Methods: This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.
Results: At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HR[SUB]adj[/SUB] (95%CI): 1.01 (1.00, 1.03)) and BMI (HR[SUB]adj[/SUB]: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.
Conclusions: In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.
Trial registration: This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).
Keywords: COVID-19; Central obesity; Obesity; Older adults; Weight loss.