tetano
Editor, Senior Moderator
BMJ Open
. 2024 Aug 17;14(8):e084770.
doi: 10.1136/bmjopen-2024-084770. Health outcomes of COVID-19 patients from Wuhan, China 3-year after hospital discharge: a cohort study
Yang Dai[SUP] #[/SUP][SUP] 1 2 [/SUP], Yan Wang[SUP] #[/SUP][SUP] 2 [/SUP], Xin Yue Yang[SUP] #[/SUP][SUP] 3 [/SUP], Qing Hua Wang[SUP] #[/SUP][SUP] 4 [/SUP], Bao Man Hu[SUP] #[/SUP][SUP] 2 [/SUP], Man Wang[SUP] #[/SUP][SUP] 2 [/SUP], Ji Jiang[SUP] 2 [/SUP], Li Xia Cheng[SUP] 5 6 [/SUP], Fu Yuan Zheng[SUP] 2 [/SUP], Ting Qin[SUP] 2 [/SUP], Ming Yang Zhang[SUP] 2 [/SUP], Yu Hui Liu[SUP] 4 7 [/SUP], Xiang Yu Ma[SUP] 8 [/SUP], Ling Zeng[SUP] 9 [/SUP], Jian Xin Jiang[SUP] 9 [/SUP], Guoqiang Cao[SUP] 2 [/SUP], Qing Xiang Mao[SUP] 1 [/SUP], Paul W Jones[SUP] 10 [/SUP], Yong He[SUP] 2 [/SUP], Cao Bin[SUP] 11 [/SUP], Li Li[SUP] 12 [/SUP]
Affiliations
Objectives: To evaluate changes in health outcomes between years 2 and 3 after discharge following COVID-19 and to identify risk factors for poor health 3-year post-discharge.
Design: This is a multicentre observational cohort study.
Setting: This study was conducted in two centres from Wuhan, China.
Participants: Eligibility screening has been performed in 3988 discharged laboratory-confirmed adult COVID-19 patients. Exclusion criteria were refusal to participate, inability to contact and death before follow-up. The WHO COVID-19 guidelines on defining disease severity were adopted.
Results: 1594 patients participated in the 1-year, 2-year and 3-year follow-ups, including 796 (49.9%) male patients, and 422 (26.5%) patients were classified in the severe disease group. 3 years after discharge, 182 (11.4%) patients still complained of at least one symptom. The most common symptoms were fatigue, myalgia, chest tightness, cough, anxiety, shortness of breath and expectoration. Fatigue or myalgia, the most common symptom cluster, frequently coexisted with chest symptoms and anxiety. Symptom persistence between years 2 and 3 was reported in 70 patients (4.4%) for which intensive care unit (ICU) admission was a risk factor (p=0.038). Of the 1586 patients who completed the chronic obstructive pulmonary disease assessment test (CAT), 97 (6.1%) scored ≥10, with older age being associated with CAT ≥10 (p=0.007).
Conclusions: Between years 2 and 3 after SARS-CoV-2 infection, most patients returned to an asymptomatic state, and only a few were still symptomatic. ICU admission was a risk factor for symptom persistence.
Keywords: COVID-19; Public health; Risk Factors.
. 2024 Aug 17;14(8):e084770.
doi: 10.1136/bmjopen-2024-084770. Health outcomes of COVID-19 patients from Wuhan, China 3-year after hospital discharge: a cohort study
Yang Dai[SUP] #[/SUP][SUP] 1 2 [/SUP], Yan Wang[SUP] #[/SUP][SUP] 2 [/SUP], Xin Yue Yang[SUP] #[/SUP][SUP] 3 [/SUP], Qing Hua Wang[SUP] #[/SUP][SUP] 4 [/SUP], Bao Man Hu[SUP] #[/SUP][SUP] 2 [/SUP], Man Wang[SUP] #[/SUP][SUP] 2 [/SUP], Ji Jiang[SUP] 2 [/SUP], Li Xia Cheng[SUP] 5 6 [/SUP], Fu Yuan Zheng[SUP] 2 [/SUP], Ting Qin[SUP] 2 [/SUP], Ming Yang Zhang[SUP] 2 [/SUP], Yu Hui Liu[SUP] 4 7 [/SUP], Xiang Yu Ma[SUP] 8 [/SUP], Ling Zeng[SUP] 9 [/SUP], Jian Xin Jiang[SUP] 9 [/SUP], Guoqiang Cao[SUP] 2 [/SUP], Qing Xiang Mao[SUP] 1 [/SUP], Paul W Jones[SUP] 10 [/SUP], Yong He[SUP] 2 [/SUP], Cao Bin[SUP] 11 [/SUP], Li Li[SUP] 12 [/SUP]
Affiliations
- PMID: 39153784
- PMCID: PMC11331845
- DOI: 10.1136/bmjopen-2024-084770
Objectives: To evaluate changes in health outcomes between years 2 and 3 after discharge following COVID-19 and to identify risk factors for poor health 3-year post-discharge.
Design: This is a multicentre observational cohort study.
Setting: This study was conducted in two centres from Wuhan, China.
Participants: Eligibility screening has been performed in 3988 discharged laboratory-confirmed adult COVID-19 patients. Exclusion criteria were refusal to participate, inability to contact and death before follow-up. The WHO COVID-19 guidelines on defining disease severity were adopted.
Results: 1594 patients participated in the 1-year, 2-year and 3-year follow-ups, including 796 (49.9%) male patients, and 422 (26.5%) patients were classified in the severe disease group. 3 years after discharge, 182 (11.4%) patients still complained of at least one symptom. The most common symptoms were fatigue, myalgia, chest tightness, cough, anxiety, shortness of breath and expectoration. Fatigue or myalgia, the most common symptom cluster, frequently coexisted with chest symptoms and anxiety. Symptom persistence between years 2 and 3 was reported in 70 patients (4.4%) for which intensive care unit (ICU) admission was a risk factor (p=0.038). Of the 1586 patients who completed the chronic obstructive pulmonary disease assessment test (CAT), 97 (6.1%) scored ≥10, with older age being associated with CAT ≥10 (p=0.007).
Conclusions: Between years 2 and 3 after SARS-CoV-2 infection, most patients returned to an asymptomatic state, and only a few were still symptomatic. ICU admission was a risk factor for symptom persistence.
Keywords: COVID-19; Public health; Risk Factors.