tetano
Editor, Senior Moderator
Brain Behav Immun
. 2020 May 25;S0889-1591(20)30483-9.
doi: 10.1016/j.bbi.2020.05.062. Online ahead of print.
Correlation Between Immune Response and Self-Reported Depression During Convalescence From COVID-19
Bo Yuan[SUP] 1 [/SUP], Weixin Li[SUP] 2 [/SUP], Hanqing Liu[SUP] 3 [/SUP], Xin Cai[SUP] 1 [/SUP], Shuo Song[SUP] 3 [/SUP], Jia Zhao[SUP] 3 [/SUP], Xiaopeng Hu[SUP] 3 [/SUP], Zhiwen Li[SUP] 3 [/SUP], Yongxin Chen[SUP] 2 [/SUP], Kai Zhang[SUP] 4 [/SUP], Zhiyong Liu[SUP] 4 [/SUP], Jing Peng[SUP] 4 [/SUP], Cheng Wang[SUP] 2 [/SUP], Jianchun Wang[SUP] 5 [/SUP], Yawen An[SUP] 6 [/SUP]
Affiliations
Abstract
Self-reported depression has been observed in coronavirus disease-2019 (COVID-19) patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during discharge from the hospital. However, the cause of this self-reported depression during the convalescent period remains unclear. Here, we report the mental health status of 96 convalescent COVID-19 patients who were surveyed using an online questionnaire at the Shenzhen Samii Medical Center from March 2 to March 12, 2020 in Shenzhen, China. After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. The results suggested that patients with self-reported depression exhibited increased immune response, as indicated by increased white blood cell and neutrophil counts, as well as neutrophil-to-lymphocyte ratio. However, the mechanism linking self-reported depression to these cellular changes needs further study. In conclusion, self-reported depression occurred at an early stage in convalescent COVID-19 patients, and changes in immune function were apparent during short-term follow-up of these patients after discharge. Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.
Keywords: blood routine analysis; convalescent COVID-19 patients; immunity response; self-reported depression.
. 2020 May 25;S0889-1591(20)30483-9.
doi: 10.1016/j.bbi.2020.05.062. Online ahead of print.
Correlation Between Immune Response and Self-Reported Depression During Convalescence From COVID-19
Bo Yuan[SUP] 1 [/SUP], Weixin Li[SUP] 2 [/SUP], Hanqing Liu[SUP] 3 [/SUP], Xin Cai[SUP] 1 [/SUP], Shuo Song[SUP] 3 [/SUP], Jia Zhao[SUP] 3 [/SUP], Xiaopeng Hu[SUP] 3 [/SUP], Zhiwen Li[SUP] 3 [/SUP], Yongxin Chen[SUP] 2 [/SUP], Kai Zhang[SUP] 4 [/SUP], Zhiyong Liu[SUP] 4 [/SUP], Jing Peng[SUP] 4 [/SUP], Cheng Wang[SUP] 2 [/SUP], Jianchun Wang[SUP] 5 [/SUP], Yawen An[SUP] 6 [/SUP]
Affiliations
- PMID: 32464158
- DOI: 10.1016/j.bbi.2020.05.062
Abstract
Self-reported depression has been observed in coronavirus disease-2019 (COVID-19) patients, infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), during discharge from the hospital. However, the cause of this self-reported depression during the convalescent period remains unclear. Here, we report the mental health status of 96 convalescent COVID-19 patients who were surveyed using an online questionnaire at the Shenzhen Samii Medical Center from March 2 to March 12, 2020 in Shenzhen, China. After obtaining their informed consent, we retrospectively analyzed the clinical characteristics of patients, including routine blood and biochemical data. The results suggested that patients with self-reported depression exhibited increased immune response, as indicated by increased white blood cell and neutrophil counts, as well as neutrophil-to-lymphocyte ratio. However, the mechanism linking self-reported depression to these cellular changes needs further study. In conclusion, self-reported depression occurred at an early stage in convalescent COVID-19 patients, and changes in immune function were apparent during short-term follow-up of these patients after discharge. Appropriate psychological interventions are necessary, and changes in immune function should be emphasized during long-term follow up of these patients.
Keywords: blood routine analysis; convalescent COVID-19 patients; immunity response; self-reported depression.