tetano
Editor, Senior Moderator
Braz J Infect Dis
. 2022 Jul 11;102385.
doi: 10.1016/j.bjid.2022.102385. Online ahead of print.
Gamma variant vertically transmitted from a mild symptomatic pregnant woman associated with fatal neonatal COVID
Walusa Assad Gonçalves-Ferri[SUP] 1 [/SUP], Cristina Galdonyi Carvalheiro[SUP] 2 [/SUP], Marisa Marcia Mussi-Pinhata[SUP] 2 [/SUP], Bruna Pinto Dias Cavasin[SUP] 3 [/SUP], Benedito Antonio Lopes da Fonseca[SUP] 3 [/SUP]
Affiliations
Abstract
Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in a pregnant woman who gave birth to a preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed to multisystem inflammatory syndrome and death on the seventh day of life. Genome sequencing detected the P.1 (gamma) variant in samples obtained at hospital admission (mother) and on the first (10h) and 13th days of life (neonate). Complete homology (mother's and newborn's sequences) confirmed vertical transmission. To our knowledge, this is the first report of vertically-transmitted SARS-CoV-2 P.1 (gamma) variant in a mild symptomatic infection in pregnancy associated with fatal COVID in a neonate.
Keywords: Covid 19; Preterm infant; Sars-CoV-2 variant; Vertical transmission.
. 2022 Jul 11;102385.
doi: 10.1016/j.bjid.2022.102385. Online ahead of print.
Gamma variant vertically transmitted from a mild symptomatic pregnant woman associated with fatal neonatal COVID
Walusa Assad Gonçalves-Ferri[SUP] 1 [/SUP], Cristina Galdonyi Carvalheiro[SUP] 2 [/SUP], Marisa Marcia Mussi-Pinhata[SUP] 2 [/SUP], Bruna Pinto Dias Cavasin[SUP] 3 [/SUP], Benedito Antonio Lopes da Fonseca[SUP] 3 [/SUP]
Affiliations
- PMID: 35835159
- DOI: 10.1016/j.bjid.2022.102385
Abstract
Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in a pregnant woman who gave birth to a preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed to multisystem inflammatory syndrome and death on the seventh day of life. Genome sequencing detected the P.1 (gamma) variant in samples obtained at hospital admission (mother) and on the first (10h) and 13th days of life (neonate). Complete homology (mother's and newborn's sequences) confirmed vertical transmission. To our knowledge, this is the first report of vertically-transmitted SARS-CoV-2 P.1 (gamma) variant in a mild symptomatic infection in pregnancy associated with fatal COVID in a neonate.
Keywords: Covid 19; Preterm infant; Sars-CoV-2 variant; Vertical transmission.