tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2017 Oct 9. doi: 10.1111/irv.12507. [Epub ahead of print]
[h=1]Burden of influenza among hospitalized febrile children in Ghana.[/h] Hogan B[SUP]1,[/SUP][SUP]2[/SUP], Ammer L[SUP]1,[/SUP][SUP]2[/SUP], Zimmermann M[SUP]1[/SUP], Binger T[SUP]3[/SUP], Krumkamp R[SUP]1,[/SUP][SUP]2[/SUP], Sarpong N[SUP]3[/SUP], Rettig T[SUP]4[/SUP], Dekker D[SUP]1,[/SUP][SUP]2[/SUP], Kreuels B[SUP]2,[/SUP][SUP]5[/SUP], Reigl L[SUP]1,[/SUP][SUP]2[/SUP], Boahen KG[SUP]3[/SUP], Wiafe C[SUP]3[/SUP], Adu-Sarkodie Y[SUP]6[/SUP], Owusu-Dabo E[SUP]3,[/SUP][SUP]7[/SUP], May J[SUP]1,[/SUP][SUP]2[/SUP], Eibach D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However local influenza data from district hospitals with limited laboratory facilities are still scarce.
[h=4]OBJECTIVES:[/h] To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.
[h=4]METHODS:[/h] Between January 2014 and April 2015 all children with a temperature of ≥38?C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.
[h=4]RESULTS:[/h] A total of 1,063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09 and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR=2.9; 95%CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria respectively.
[h=4]CONCLUSION:[/h] Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 28991406 DOI: 10.1111/irv.12507
Free full text
[h=1]Burden of influenza among hospitalized febrile children in Ghana.[/h] Hogan B[SUP]1,[/SUP][SUP]2[/SUP], Ammer L[SUP]1,[/SUP][SUP]2[/SUP], Zimmermann M[SUP]1[/SUP], Binger T[SUP]3[/SUP], Krumkamp R[SUP]1,[/SUP][SUP]2[/SUP], Sarpong N[SUP]3[/SUP], Rettig T[SUP]4[/SUP], Dekker D[SUP]1,[/SUP][SUP]2[/SUP], Kreuels B[SUP]2,[/SUP][SUP]5[/SUP], Reigl L[SUP]1,[/SUP][SUP]2[/SUP], Boahen KG[SUP]3[/SUP], Wiafe C[SUP]3[/SUP], Adu-Sarkodie Y[SUP]6[/SUP], Owusu-Dabo E[SUP]3,[/SUP][SUP]7[/SUP], May J[SUP]1,[/SUP][SUP]2[/SUP], Eibach D[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza surveillance data from Africa indicate a substantial disease burden with high mortality. However local influenza data from district hospitals with limited laboratory facilities are still scarce.
[h=4]OBJECTIVES:[/h] To identify the frequency and seasonal distribution of influenza among hospitalized febrile children in a rural hospital in Ghana and to describe differential diagnoses to other severe febrile infections.
[h=4]METHODS:[/h] Between January 2014 and April 2015 all children with a temperature of ≥38?C admitted to a district hospital in Ghana were screened for influenza A and B by RT-PCR and differentiated to subtypes A(H1N1)pdm09 and A(H3N2). Malaria microscopy and blood cultures were performed for each patient.
[h=4]RESULTS:[/h] A total of 1,063 children with a median age of 2 years (IQR: 1-4 years) were recruited. Of those, 271 (21%) were classified as severe acute respiratory infection (SARI) and 47 (4%) were positive for influenza, namely 26 (55%) influenza B, 15 (32%) A(H1N1)pdm09 and 6 (13%) A(H3N2) cases. Influenza predominantly occurred in children aged 3-5 years and was more frequently detected in the major rainy season (OR=2.9; 95%CI: 1.47-6.19) during the first half of the year. Two (4%) and seven (15%) influenza-positive children were co-diagnosed with an invasive bloodstream infection or malaria respectively.
[h=4]CONCLUSION:[/h] Influenza contributes substantially to the burden of hospitalized febrile children in Ghana being strongly dependent on age and corresponds with the major rainy season during the first half-year. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 28991406 DOI: 10.1111/irv.12507
Free full text