tetano
Editor, Senior Moderator
Vaccine. 2014 Oct 2. pii: S0264-410X(14)01319-X. doi: 10.1016/j.vaccine.2014.09.051. [Epub ahead of print]
Can the rolling cross-sectional survey design be used to estimate the effectiveness of influenza vaccines?
Donahue JG1, Kieke BA2, Szilagy PG3, Blumkin AK3, Hilgemann D2, Dana Flanders W4, Shay DK5, Meece J2, Gallivan S3, Treanor J3, Belongia EA2.
Author information
Abstract
INTRODUCTION:
Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design and laboratory confirmation of influenza.
METHODS:
Cross-sectional samples were selected weekly from defined populations in Marshfield, Wisconsin and Monroe County, New York from January through April, 2011 (12 weeks). Persons were telephoned and asked about the occurrence of ARI in the past week. Nasal and throat swabs were obtained from consenting individuals with ARI and tested by real-time reverse transcription polymerase chain reaction (RT-PCR). Vaccine effectiveness (VE) was defined as (100?[1-OR]) for vaccination in a logistic regression model that adjusted for age, calendar week, and site. The comparison group included all study participants without RT-PCR confirmed influenza, including those who were not ill.
RESULTS:
Study personnel contacted 9537 (62%) of 15,303 persons sampled; the primary analysis included 5678 subjects. Of these, 193 (3%) reported an ARI and agreed to be tested for influenza; 13 (7%) were influenza positive. The adjusted effectiveness of the influenza vaccine was 1% (95% confidence limits -239-70%).
CONCLUSIONS:
The rolling cross-sectional design is methodologically feasible and may be useful as a complement to clinic-based VE studies. This pilot study did not have sufficient power to detect significant vaccine effectiveness during a mild influenza season, but this approach may facilitate rapid estimation of VE in a pandemic setting when normal patterns of health care utilization are disrupted.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Influenza vaccine; Rolling cross section; Vaccine effectiveness
PMID:
25284810
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25284810
Can the rolling cross-sectional survey design be used to estimate the effectiveness of influenza vaccines?
Donahue JG1, Kieke BA2, Szilagy PG3, Blumkin AK3, Hilgemann D2, Dana Flanders W4, Shay DK5, Meece J2, Gallivan S3, Treanor J3, Belongia EA2.
Author information
Abstract
INTRODUCTION:
Observational studies of influenza vaccine effectiveness often study persons seeking medical care for acute respiratory infection (ARI). We conducted a pilot study to determine if vaccine effectiveness could be estimated in the general population with a novel rolling cross-sectional survey sampling design and laboratory confirmation of influenza.
METHODS:
Cross-sectional samples were selected weekly from defined populations in Marshfield, Wisconsin and Monroe County, New York from January through April, 2011 (12 weeks). Persons were telephoned and asked about the occurrence of ARI in the past week. Nasal and throat swabs were obtained from consenting individuals with ARI and tested by real-time reverse transcription polymerase chain reaction (RT-PCR). Vaccine effectiveness (VE) was defined as (100?[1-OR]) for vaccination in a logistic regression model that adjusted for age, calendar week, and site. The comparison group included all study participants without RT-PCR confirmed influenza, including those who were not ill.
RESULTS:
Study personnel contacted 9537 (62%) of 15,303 persons sampled; the primary analysis included 5678 subjects. Of these, 193 (3%) reported an ARI and agreed to be tested for influenza; 13 (7%) were influenza positive. The adjusted effectiveness of the influenza vaccine was 1% (95% confidence limits -239-70%).
CONCLUSIONS:
The rolling cross-sectional design is methodologically feasible and may be useful as a complement to clinic-based VE studies. This pilot study did not have sufficient power to detect significant vaccine effectiveness during a mild influenza season, but this approach may facilitate rapid estimation of VE in a pandemic setting when normal patterns of health care utilization are disrupted.
Copyright ? 2014. Published by Elsevier Ltd.
KEYWORDS:
Influenza vaccine; Rolling cross section; Vaccine effectiveness
PMID:
25284810
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25284810