tetano
Editor, Senior Moderator
Card Electrophysiol Clin
. 2022 Mar;14(1):29-39.
doi: 10.1016/j.ccep.2021.10.004. Epub 2021 Oct 30.
COVID-19, Acute Myocardial Injury, and Infarction
Armando Del Prete[SUP] 1 [/SUP], Francesca Conway[SUP] 2 [/SUP], Domenico G Della Rocca[SUP] 3 [/SUP], Giuseppe Biondi-Zoccai[SUP] 4 [/SUP], Francesco De Felice[SUP] 5 [/SUP], Carmine Musto[SUP] 5 [/SUP], Marco Picichè[SUP] 6 [/SUP], Eugenio Martuscelli[SUP] 7 [/SUP], Andrea Natale[SUP] 8 [/SUP], Francesco Versaci[SUP] 9 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus-2 can affect the cardiovascular system yielding a wide range of complications, including acute myocardial injury. The myocardium can be damaged by direct viral invasion or indirect mechanisms, sustained by systemic inflammation, immune-mediated response, and dysregulation of the renin-angiotensin system. Myocardial injury affects about one-quarter of patients with COVID-19, can manifest even in the absence of previous cardiovascular disease, and is associated to higher mortality rates and long-term sequelae. This review describes the pathophysiological mechanisms of myocardial injury and infarction and discusses the main clinical outcomes and diagnostic challenges associated with myocardial damage during COVID-19.
Keywords: COVID-19; Myocardial infarction; Myocardial injury; SARS-CoV-2.
. 2022 Mar;14(1):29-39.
doi: 10.1016/j.ccep.2021.10.004. Epub 2021 Oct 30.
COVID-19, Acute Myocardial Injury, and Infarction
Armando Del Prete[SUP] 1 [/SUP], Francesca Conway[SUP] 2 [/SUP], Domenico G Della Rocca[SUP] 3 [/SUP], Giuseppe Biondi-Zoccai[SUP] 4 [/SUP], Francesco De Felice[SUP] 5 [/SUP], Carmine Musto[SUP] 5 [/SUP], Marco Picichè[SUP] 6 [/SUP], Eugenio Martuscelli[SUP] 7 [/SUP], Andrea Natale[SUP] 8 [/SUP], Francesco Versaci[SUP] 9 [/SUP]
Affiliations
- PMID: 35221083
- DOI: 10.1016/j.ccep.2021.10.004
Abstract
Severe acute respiratory syndrome coronavirus-2 can affect the cardiovascular system yielding a wide range of complications, including acute myocardial injury. The myocardium can be damaged by direct viral invasion or indirect mechanisms, sustained by systemic inflammation, immune-mediated response, and dysregulation of the renin-angiotensin system. Myocardial injury affects about one-quarter of patients with COVID-19, can manifest even in the absence of previous cardiovascular disease, and is associated to higher mortality rates and long-term sequelae. This review describes the pathophysiological mechanisms of myocardial injury and infarction and discusses the main clinical outcomes and diagnostic challenges associated with myocardial damage during COVID-19.
Keywords: COVID-19; Myocardial infarction; Myocardial injury; SARS-CoV-2.