tetano
Editor, Senior Moderator
Card Fail Rev
. 2020 May 25;6:e15.
doi: 10.15420/cfr.2020.10. eCollection 2020 Mar.
Mechanisms of Myocardial Injury in Coronavirus Disease 2019
Aniket S Rali[SUP] 1 [/SUP], Sagar Ranka[SUP] 2 [/SUP], Zubair Shah[SUP] 2 [/SUP], Andrew J Sauer[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) predominantly presents with symptoms of fever, fatigue, cough and respiratory failure. However, it appears to have a unique interplay with cardiovascular disease (CVD); patients with pre-existing CVD are at highest risk for mortality from COVID-19, along with the elderly. COVID-19 contributes to cardiovascular complications including arrhythmias, myocardial dysfunction and myocardial inflammation. Although the exact mechanism of myocardial inflammation in patients with COVID-19 is not known, several plausible mechanisms have been proposed based on early observational reports. In this article, the authors summarise the available literature on mechanisms of myocardial injury in COVID-19.
Keywords: ACE-2 receptors; COVID-19; Myocardial injury; cardiac failure; myocarditis.
. 2020 May 25;6:e15.
doi: 10.15420/cfr.2020.10. eCollection 2020 Mar.
Mechanisms of Myocardial Injury in Coronavirus Disease 2019
Aniket S Rali[SUP] 1 [/SUP], Sagar Ranka[SUP] 2 [/SUP], Zubair Shah[SUP] 2 [/SUP], Andrew J Sauer[SUP] 2 [/SUP]
Affiliations
- PMID: 32537248
- PMCID: PMC7277776
- DOI: 10.15420/cfr.2020.10
Abstract
Coronavirus disease 2019 (COVID-19) predominantly presents with symptoms of fever, fatigue, cough and respiratory failure. However, it appears to have a unique interplay with cardiovascular disease (CVD); patients with pre-existing CVD are at highest risk for mortality from COVID-19, along with the elderly. COVID-19 contributes to cardiovascular complications including arrhythmias, myocardial dysfunction and myocardial inflammation. Although the exact mechanism of myocardial inflammation in patients with COVID-19 is not known, several plausible mechanisms have been proposed based on early observational reports. In this article, the authors summarise the available literature on mechanisms of myocardial injury in COVID-19.
Keywords: ACE-2 receptors; COVID-19; Myocardial injury; cardiac failure; myocarditis.