tetano
Editor, Senior Moderator
Cardiol Young
. 2023 Jun 29;1-10.
doi: 10.1017/S1047951123001348. Online ahead of print. Cardiovascular manifestations and cardiac magnetic resonance follow-up of multisystem inflammatory syndrome in children (MIS-C)
Selen Karagözlü[SUP] 1 [/SUP], Mehmet G Ramoğlu[SUP] 1 [/SUP], Özlem Bayram[SUP] 1 [/SUP], Jeyhun Bakhtiyarzada[SUP] 1 [/SUP], Alperen Aydın[SUP] 1 [/SUP], Mehmet Mustafa Yılmaz[SUP] 1 [/SUP], Begüm Murt[SUP] 1 [/SUP], Ersin Özkan[SUP] 2 [/SUP], Hatice Belkıs İnceli[SUP] 3 [/SUP], Anar Gurbanov[SUP] 4 [/SUP], Yılmaz Şükriye[SUP] 5 [/SUP], Berrin Demir[SUP] 5 [/SUP], Halil Özdemir[SUP] 3 [/SUP], Ergin Çiftçi[SUP] 3 [/SUP], Tanıl Kendirli[SUP] 4 [/SUP], Tayfun Uçar[SUP] 1 [/SUP], Ömer Suat Fitoz[SUP] 5 [/SUP], Ercan Tutar[SUP] 1 [/SUP]
Affiliations
Objective: This study aimed to evaluate the cardiovascular manifestations and surveillance of multisystem inflammatory syndrome in children (MIS-C) and to determine the correlation of echocardiographic findings with cardiac magnetic resonance imaging findings.
Methods: Forty-four children diagnosed as MIS-C with cardiac involvement were enrolled in this observational descriptive study. The diagnosis of MIS-C was made according to the criteria of Centers for Disease Control and Prevention. Clinical findings, laboratory parameters, and electrocardiographic and echocardiographic findings at the time of diagnosis and during follow-up were evaluated. Cardiac magnetic resonance was performed on 28 (64%) cases. The 1-year follow-up imaging was performed in all cases with abnormal initial cardiac magnetic resonance findings.
Results: Forty-four patients (56.8% male) with a mean age of 8.5 ± 4.8 years were enrolled in this study. There was a significant positive correlation between high-sensitivity cardiac troponin T (mean: 162 ± 444.4 pg/ml) and N-terminal pro b-type natriuretic peptide (mean: 10,054 ± 11,604 pg/ml) (p < 0.01). Number of cases with an electrocardiographic and echocardiographic abnormality was 34 (77%) and 31 (70%), respectively. Twelve cases (45%) had left ventricular systolic dysfunction and 14 (32%) cases had pericardial effusion on admission. Three cases (11%) had cardiac magnetic resonance findings that may be attributed to the presence of myocardial inflammation, and pericardial effusion was present in seven (25%) cases. Follow-up cardiac magnetic resonances of all cases were normal. Cardiac abnormalities were completely resolved in all except two cases.
Conclusions: Myocardial involvement can be seen during acute disease, but MIS-C generally does not lead to prominent damage during a year of surveillance. Cardiac magnetic resonance is a valuable tool to evaluate the degree of myocardial involvement in cases with MIS-C.
Keywords: Multisystem inflammatory syndrome in children; cardiac magnetic resonance; cardiovascular; coronavirus disease-2019.
. 2023 Jun 29;1-10.
doi: 10.1017/S1047951123001348. Online ahead of print. Cardiovascular manifestations and cardiac magnetic resonance follow-up of multisystem inflammatory syndrome in children (MIS-C)
Selen Karagözlü[SUP] 1 [/SUP], Mehmet G Ramoğlu[SUP] 1 [/SUP], Özlem Bayram[SUP] 1 [/SUP], Jeyhun Bakhtiyarzada[SUP] 1 [/SUP], Alperen Aydın[SUP] 1 [/SUP], Mehmet Mustafa Yılmaz[SUP] 1 [/SUP], Begüm Murt[SUP] 1 [/SUP], Ersin Özkan[SUP] 2 [/SUP], Hatice Belkıs İnceli[SUP] 3 [/SUP], Anar Gurbanov[SUP] 4 [/SUP], Yılmaz Şükriye[SUP] 5 [/SUP], Berrin Demir[SUP] 5 [/SUP], Halil Özdemir[SUP] 3 [/SUP], Ergin Çiftçi[SUP] 3 [/SUP], Tanıl Kendirli[SUP] 4 [/SUP], Tayfun Uçar[SUP] 1 [/SUP], Ömer Suat Fitoz[SUP] 5 [/SUP], Ercan Tutar[SUP] 1 [/SUP]
Affiliations
- PMID: 37381829
- DOI: 10.1017/S1047951123001348
Objective: This study aimed to evaluate the cardiovascular manifestations and surveillance of multisystem inflammatory syndrome in children (MIS-C) and to determine the correlation of echocardiographic findings with cardiac magnetic resonance imaging findings.
Methods: Forty-four children diagnosed as MIS-C with cardiac involvement were enrolled in this observational descriptive study. The diagnosis of MIS-C was made according to the criteria of Centers for Disease Control and Prevention. Clinical findings, laboratory parameters, and electrocardiographic and echocardiographic findings at the time of diagnosis and during follow-up were evaluated. Cardiac magnetic resonance was performed on 28 (64%) cases. The 1-year follow-up imaging was performed in all cases with abnormal initial cardiac magnetic resonance findings.
Results: Forty-four patients (56.8% male) with a mean age of 8.5 ± 4.8 years were enrolled in this study. There was a significant positive correlation between high-sensitivity cardiac troponin T (mean: 162 ± 444.4 pg/ml) and N-terminal pro b-type natriuretic peptide (mean: 10,054 ± 11,604 pg/ml) (p < 0.01). Number of cases with an electrocardiographic and echocardiographic abnormality was 34 (77%) and 31 (70%), respectively. Twelve cases (45%) had left ventricular systolic dysfunction and 14 (32%) cases had pericardial effusion on admission. Three cases (11%) had cardiac magnetic resonance findings that may be attributed to the presence of myocardial inflammation, and pericardial effusion was present in seven (25%) cases. Follow-up cardiac magnetic resonances of all cases were normal. Cardiac abnormalities were completely resolved in all except two cases.
Conclusions: Myocardial involvement can be seen during acute disease, but MIS-C generally does not lead to prominent damage during a year of surveillance. Cardiac magnetic resonance is a valuable tool to evaluate the degree of myocardial involvement in cases with MIS-C.
Keywords: Multisystem inflammatory syndrome in children; cardiac magnetic resonance; cardiovascular; coronavirus disease-2019.