tetano
Editor, Senior Moderator
J Reprod Immunol. 2014 Oct 13. pii: S0165-0378(14)00137-5. doi: 10.1016/j.jri.2014.09.051. [Epub ahead of print]
CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection.
Vanders RL1, Murphy VE2, Gibson PG3, Hansbro PM4, Wark PA5.
Author information
Abstract
Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.
Copyright ? 2014 Elsevier Ireland Ltd. All rights reserved.
KEYWORDS:
CD8T cells; Dendritic cells (DCs); H1N1pdm09; Infection; Influenza; Pregnancy
PMID:
25453203
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25453203
CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection.
Vanders RL1, Murphy VE2, Gibson PG3, Hansbro PM4, Wark PA5.
Author information
Abstract
Pregnancy provides a unique challenge for maternal immunity, requiring the ability to tolerate the presence of a semi-allogeneic foetus, and yet still being capable of inducing an immune response against invading pathogens. To achieve this, numerous changes must occur in the activity and function of maternal immune cells throughout the course of pregnancy. Respiratory viruses take advantage of these changes, altering the sensitive balance of maternal immunity, leaving the mother with increased susceptibility to viral infections and increased disease severity. Influenza virus is one of the most common respiratory virus infections during pregnancy, leading to an increased risk of ICU hospitalisations, pneumonia, acute respiratory distress syndrome and even death. Whilst much research has been performed to understand the changes that must take place in maternal immunity during pregnancy, considerable work is still needed to fully comprehend this tremendous feat. To date, few studies have focused on the alterations that occur in maternal immunity during respiratory virus infections. This review highlights the role of dendritic cells (DCs) and CD8 T cells during pregnancy, and the changes that occur in these antiviral cells following influenza virus infections.
Copyright ? 2014 Elsevier Ireland Ltd. All rights reserved.
KEYWORDS:
CD8T cells; Dendritic cells (DCs); H1N1pdm09; Infection; Influenza; Pregnancy
PMID:
25453203
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/25453203