tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2015 Apr 15:0. [Epub ahead of print]
Cell culture-based influenza vaccines: a necessary and indispensable investment for the future.
Hegde NR[SUP]1[/SUP].
Author information
Abstract
The traditional platform of using embryonated chicken eggs for the production of influenza vaccines has several drawbacks including the inability to meet the volume of required doses in the case of widespread epidemics and pandemics. Cell culture platforms have therefore been explored in the last two decades, and have attracted further attention following the H1N1 pandemic outbreak. This platform, while not the most economical for large-scale production, has several advantages, and can supplement the vaccine requirement when needed. Recent developments in production technologies have contributed greatly to fine-tuning this platform. In combination with other technologies such as live attenuated and recombinant protein or virus-like particle vaccines, and different adjuvants and delivery systems, cell culture-based influenza vaccine platform can be used both for production of seasonal vaccine, and to mitigate vaccine shortages in pandemic situations.
KEYWORDS:
adverse events; cell culture; drawbacks; efficacy; egg-based; immunogenicity; influenza; vaccine
PMID: 25875691 [PubMed - as supplied by publisher]
Cell culture-based influenza vaccines: a necessary and indispensable investment for the future.
Hegde NR[SUP]1[/SUP].
Author information
Abstract
The traditional platform of using embryonated chicken eggs for the production of influenza vaccines has several drawbacks including the inability to meet the volume of required doses in the case of widespread epidemics and pandemics. Cell culture platforms have therefore been explored in the last two decades, and have attracted further attention following the H1N1 pandemic outbreak. This platform, while not the most economical for large-scale production, has several advantages, and can supplement the vaccine requirement when needed. Recent developments in production technologies have contributed greatly to fine-tuning this platform. In combination with other technologies such as live attenuated and recombinant protein or virus-like particle vaccines, and different adjuvants and delivery systems, cell culture-based influenza vaccine platform can be used both for production of seasonal vaccine, and to mitigate vaccine shortages in pandemic situations.
KEYWORDS:
adverse events; cell culture; drawbacks; efficacy; egg-based; immunogenicity; influenza; vaccine
PMID: 25875691 [PubMed - as supplied by publisher]