tetano
Editor, Senior Moderator
Cell Rep
. 2021 Aug 13;109637.
doi: 10.1016/j.celrep.2021.109637. Online ahead of print.
Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose
Nicholas S Rhoades[SUP] 1 [/SUP], Amanda N Pinski[SUP] 1 [/SUP], Alisha N Monsibais[SUP] 1 [/SUP], Allen Jankeel[SUP] 1 [/SUP], Brianna M Doratt[SUP] 1 [/SUP], Isaac R Cinco[SUP] 1 [/SUP], Izabela Ibraim[SUP] 1 [/SUP], Ilhem Messaoudi[SUP] 2 [/SUP]
Affiliations
Abstract
Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies investigating the impact of acute SARS-CoV-2 at the site of infection. We show that the nasal microbiome of SARS-CoV-2-positive patients (CoV[SUP]+[/SUP], n = 68) at the time of diagnosis is unique when compared to CoV[SUP]-[/SUP] healthcare workers (n = 45) and CoV[SUP]-[/SUP] outpatients (n = 21). This shift is marked by an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa, which is also positively associated with viral RNA load. Additionally, we observe a robust host transcriptional response in the nasal epithelia of CoV[SUP]+[/SUP] patients, indicative of an antiviral innate immune response and neuronal damage. These data suggest that the inflammatory response caused by SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens in the nasal cavity that could contribute to increased incidence of secondary bacterial infections.
Keywords: COVID-19; Pseudomonas aeruginosa; RNA-seq; SARS-CoV-2; coinfection; inflammation; nasal microbiome; viral RNA load.
. 2021 Aug 13;109637.
doi: 10.1016/j.celrep.2021.109637. Online ahead of print.
Acute SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa in the nose
Nicholas S Rhoades[SUP] 1 [/SUP], Amanda N Pinski[SUP] 1 [/SUP], Alisha N Monsibais[SUP] 1 [/SUP], Allen Jankeel[SUP] 1 [/SUP], Brianna M Doratt[SUP] 1 [/SUP], Isaac R Cinco[SUP] 1 [/SUP], Izabela Ibraim[SUP] 1 [/SUP], Ilhem Messaoudi[SUP] 2 [/SUP]
Affiliations
- PMID: 34433082
- DOI: 10.1016/j.celrep.2021.109637
Abstract
Research conducted on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis and coronavirus disease 2019 (COVID-19) generally focuses on the systemic host response, especially that generated by severely ill patients, with few studies investigating the impact of acute SARS-CoV-2 at the site of infection. We show that the nasal microbiome of SARS-CoV-2-positive patients (CoV[SUP]+[/SUP], n = 68) at the time of diagnosis is unique when compared to CoV[SUP]-[/SUP] healthcare workers (n = 45) and CoV[SUP]-[/SUP] outpatients (n = 21). This shift is marked by an increased abundance of bacterial pathogens, including Pseudomonas aeruginosa, which is also positively associated with viral RNA load. Additionally, we observe a robust host transcriptional response in the nasal epithelia of CoV[SUP]+[/SUP] patients, indicative of an antiviral innate immune response and neuronal damage. These data suggest that the inflammatory response caused by SARS-CoV-2 infection is associated with an increased abundance of bacterial pathogens in the nasal cavity that could contribute to increased incidence of secondary bacterial infections.
Keywords: COVID-19; Pseudomonas aeruginosa; RNA-seq; SARS-CoV-2; coinfection; inflammation; nasal microbiome; viral RNA load.