tetano
Editor, Senior Moderator
Cell Rep
. 2021 Jun 29;109414.
doi: 10.1016/j.celrep.2021.109414. Online ahead of print.
Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19
Jason Neidleman[SUP] 1 [/SUP], Xiaoyu Luo[SUP] 2 [/SUP], Ashley F George[SUP] 1 [/SUP], Matthew McGregor[SUP] 1 [/SUP], Junkai Yang[SUP] 3 [/SUP], Cassandra Yun[SUP] 4 [/SUP], Victoria Murray[SUP] 5 [/SUP], Gurjot Gill[SUP] 5 [/SUP], Warner C Greene[SUP] 6 [/SUP], Joshua Vasquez[SUP] 7 [/SUP], Sulggi A Lee[SUP] 5 [/SUP], Eliver Ghosn[SUP] 8 [/SUP], Kara L Lynch[SUP] 9 [/SUP], Nadia R Roan[SUP] 10 [/SUP]
Affiliations
Abstract
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID-19 with severity ranging from mild (outpatient) to critical, culminating in death. Relative to individuals who succumbed, individuals who recovered from severe COVID-19 harbor elevated and increasing numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 cases display elevated numbers of SARS-CoV-2-specific regulatory T cells and a time-dependent escalation in activated bystander CXCR4[SUP]+[/SUP] T cells, as assessed by longitudinal sampling. Together with the demonstration of increased proportions of inflammatory CXCR4[SUP]+[/SUP] T cells in the lungs of individuals with severe COVID-19, these results support a model where lung-homing T cells activated through bystander effects contribute to immunopathology, whereas a robust, non-suppressive SARS-CoV-2-specific T cell response limits pathogenesis and promotes recovery from severe COVID-19.
Keywords: CD127; COVID-19; CXCR4; SARS-CoV-2; T cells; lung.
. 2021 Jun 29;109414.
doi: 10.1016/j.celrep.2021.109414. Online ahead of print.
Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19
Jason Neidleman[SUP] 1 [/SUP], Xiaoyu Luo[SUP] 2 [/SUP], Ashley F George[SUP] 1 [/SUP], Matthew McGregor[SUP] 1 [/SUP], Junkai Yang[SUP] 3 [/SUP], Cassandra Yun[SUP] 4 [/SUP], Victoria Murray[SUP] 5 [/SUP], Gurjot Gill[SUP] 5 [/SUP], Warner C Greene[SUP] 6 [/SUP], Joshua Vasquez[SUP] 7 [/SUP], Sulggi A Lee[SUP] 5 [/SUP], Eliver Ghosn[SUP] 8 [/SUP], Kara L Lynch[SUP] 9 [/SUP], Nadia R Roan[SUP] 10 [/SUP]
Affiliations
- PMID: 34260965
- DOI: 10.1016/j.celrep.2021.109414
Abstract
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2-specific T cells associated with recovery from severe coronavirus disease 2019 (COVID-19). We analyze T cells from 34 individuals with COVID-19 with severity ranging from mild (outpatient) to critical, culminating in death. Relative to individuals who succumbed, individuals who recovered from severe COVID-19 harbor elevated and increasing numbers of SARS-CoV-2-specific T cells capable of homeostatic proliferation. In contrast, fatal COVID-19 cases display elevated numbers of SARS-CoV-2-specific regulatory T cells and a time-dependent escalation in activated bystander CXCR4[SUP]+[/SUP] T cells, as assessed by longitudinal sampling. Together with the demonstration of increased proportions of inflammatory CXCR4[SUP]+[/SUP] T cells in the lungs of individuals with severe COVID-19, these results support a model where lung-homing T cells activated through bystander effects contribute to immunopathology, whereas a robust, non-suppressive SARS-CoV-2-specific T cell response limits pathogenesis and promotes recovery from severe COVID-19.
Keywords: CD127; COVID-19; CXCR4; SARS-CoV-2; T cells; lung.