tetano
Editor, Senior Moderator
Cell Rep Med
. 2022 Sep 19;100764.
doi: 10.1016/j.xcrm.2022.100764. Online ahead of print.
Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection
Hye Won Jeong[SUP] 1 [/SUP], Se-Mi Kim[SUP] 2 [/SUP], Min Kyung Jung[SUP] 3 [/SUP], Ji Yun Noh[SUP] 4 [/SUP], Ji-Seung Yoo[SUP] 2 [/SUP], Eun-Ha Kim[SUP] 5 [/SUP], Young-Il Kim[SUP] 2 [/SUP], Kwangmin Yu[SUP] 5 [/SUP], Seung-Gyu Jang[SUP] 6 [/SUP], Juryeon Gil[SUP] 5 [/SUP], Mark Anthony Casel[SUP] 6 [/SUP], Rollon Rare[SUP] 6 [/SUP], Jeong Ho Choi[SUP] 5 [/SUP], Hee-Sung Kim[SUP] 1 [/SUP], Jun Hyoung Kim[SUP] 7 [/SUP], Jihye Um[SUP] 8 [/SUP], Chaeyoon Kim[SUP] 3 [/SUP], Yeonjae Kim[SUP] 9 [/SUP], Bum Sik Chin[SUP] 9 [/SUP], Sungmin Jung[SUP] 10 [/SUP], Jun Yong Choi[SUP] 11 [/SUP], Kyoung-Ho Song[SUP] 12 [/SUP], Yong-Dae Kim[SUP] 13 [/SUP], Jun-Sun Park[SUP] 8 [/SUP], Joon Young Song[SUP] 14 [/SUP], Eui-Cheol Shin[SUP] 15 [/SUP], Young Ki Choi[SUP] 16 [/SUP]
Affiliations
Abstract
Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade neutralization. Here, we report that neutralizing antibodies against Omicron variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses or after two-dose mRNA vaccination. Compared with two-dose vaccination, a three-dose vaccination course induces broad neutralizing antibody responses with improved durability against different SARS-CoV-2 variants, although neutralizing antibody titers against Omicron remain low. Intriguingly, among individuals with three-dose vaccination, Omicron breakthrough infection substantially augments serum neutralizing activity against a broad spectrum of SARS-CoV-2 variants, including Omicron variants BA.1, BA.2, and BA.5. Additionally, after Omicron breakthrough infection, memory T cells respond to the spike proteins of both ancestral and Omicron SARS-CoV-2 by producing cytokines with polyfunctionality. These results suggest that Omicron breakthrough infection following three-dose mRNA vaccination induces pan-SARS-CoV-2 immunity that may protect against emerging SARS-CoV-2 variants of concern.
Keywords: D614G; Omicron BA.1; Omicron BA.2; SARS-CoV-2; T cell immune response; ancestral; breakthrough infection; cross-neutralization; mRNA vaccine; recovered patient; variants of concern.
. 2022 Sep 19;100764.
doi: 10.1016/j.xcrm.2022.100764. Online ahead of print.
Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection
Hye Won Jeong[SUP] 1 [/SUP], Se-Mi Kim[SUP] 2 [/SUP], Min Kyung Jung[SUP] 3 [/SUP], Ji Yun Noh[SUP] 4 [/SUP], Ji-Seung Yoo[SUP] 2 [/SUP], Eun-Ha Kim[SUP] 5 [/SUP], Young-Il Kim[SUP] 2 [/SUP], Kwangmin Yu[SUP] 5 [/SUP], Seung-Gyu Jang[SUP] 6 [/SUP], Juryeon Gil[SUP] 5 [/SUP], Mark Anthony Casel[SUP] 6 [/SUP], Rollon Rare[SUP] 6 [/SUP], Jeong Ho Choi[SUP] 5 [/SUP], Hee-Sung Kim[SUP] 1 [/SUP], Jun Hyoung Kim[SUP] 7 [/SUP], Jihye Um[SUP] 8 [/SUP], Chaeyoon Kim[SUP] 3 [/SUP], Yeonjae Kim[SUP] 9 [/SUP], Bum Sik Chin[SUP] 9 [/SUP], Sungmin Jung[SUP] 10 [/SUP], Jun Yong Choi[SUP] 11 [/SUP], Kyoung-Ho Song[SUP] 12 [/SUP], Yong-Dae Kim[SUP] 13 [/SUP], Jun-Sun Park[SUP] 8 [/SUP], Joon Young Song[SUP] 14 [/SUP], Eui-Cheol Shin[SUP] 15 [/SUP], Young Ki Choi[SUP] 16 [/SUP]
Affiliations
- PMID: 36182684
- DOI: 10.1016/j.xcrm.2022.100764
Abstract
Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade neutralization. Here, we report that neutralizing antibodies against Omicron variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses or after two-dose mRNA vaccination. Compared with two-dose vaccination, a three-dose vaccination course induces broad neutralizing antibody responses with improved durability against different SARS-CoV-2 variants, although neutralizing antibody titers against Omicron remain low. Intriguingly, among individuals with three-dose vaccination, Omicron breakthrough infection substantially augments serum neutralizing activity against a broad spectrum of SARS-CoV-2 variants, including Omicron variants BA.1, BA.2, and BA.5. Additionally, after Omicron breakthrough infection, memory T cells respond to the spike proteins of both ancestral and Omicron SARS-CoV-2 by producing cytokines with polyfunctionality. These results suggest that Omicron breakthrough infection following three-dose mRNA vaccination induces pan-SARS-CoV-2 immunity that may protect against emerging SARS-CoV-2 variants of concern.
Keywords: D614G; Omicron BA.1; Omicron BA.2; SARS-CoV-2; T cell immune response; ancestral; breakthrough infection; cross-neutralization; mRNA vaccine; recovered patient; variants of concern.