tetano
Editor, Senior Moderator
Cell Rep
. 2022 May 25;110938.
doi: 10.1016/j.celrep.2022.110938. Online ahead of print.
Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection
Suhas Sureshchandra[SUP] 1 [/SUP], Michael Z Zulu[SUP] 1 [/SUP], Brianna M Doratt[SUP] 2 [/SUP], Allen Jankeel[SUP] 3 [/SUP], Delia Tifrea[SUP] 4 [/SUP], Robert Edwards[SUP] 4 [/SUP], Monica Rincon[SUP] 5 [/SUP], Nicole E Marshall[SUP] 5 [/SUP], Ilhem Messaoudi[SUP] 6 [/SUP]
Affiliations
Abstract
While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild disease in pregnant women. We report attenuated antigen presentation and type I interferon (IFN) signaling pathways, loss of tissue-resident decidual macrophages, and upregulated cytokine/chemokine signaling in monocyte-derived decidual macrophages. Furthermore, we describe increased frequencies of activated tissue-resident T cells and decreased abundance of regulatory T cells with infection while frequencies of cytotoxic CD4/CD8 T cells are increased in the blood. In contrast to decidual macrophages, type I IFN signaling is higher in decidual T cells. Finally, infection leads to a narrowing of T cell receptor diversity in both blood and decidua. Collectively, these observations indicate that asymptomatic/mild COVID-19 during pregnancy results in remodeling of the immunological landscape of the maternal-fetal interface, with a potential for long-term adverse outcomes for the offspring.
Keywords: COVID-19; CP: Immunology; CP: Microbiology; SARS-CoV-2; T cells; TCR; decidua; macrophages; placenta; pregnancy.
. 2022 May 25;110938.
doi: 10.1016/j.celrep.2022.110938. Online ahead of print.
Single-cell RNA sequencing reveals immunological rewiring at the maternal-fetal interface following asymptomatic/mild SARS-CoV-2 infection
Suhas Sureshchandra[SUP] 1 [/SUP], Michael Z Zulu[SUP] 1 [/SUP], Brianna M Doratt[SUP] 2 [/SUP], Allen Jankeel[SUP] 3 [/SUP], Delia Tifrea[SUP] 4 [/SUP], Robert Edwards[SUP] 4 [/SUP], Monica Rincon[SUP] 5 [/SUP], Nicole E Marshall[SUP] 5 [/SUP], Ilhem Messaoudi[SUP] 6 [/SUP]
Affiliations
- PMID: 35662411
- DOI: 10.1016/j.celrep.2022.110938
Abstract
While severe coronavirus 2019 (COVID-19) is associated with immune activation at the maternal-fetal interface, responses to asymptomatic/mild severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy remain unknown. Here, we assess immunological adaptations in blood and term decidua in response to asymptomatic/mild disease in pregnant women. We report attenuated antigen presentation and type I interferon (IFN) signaling pathways, loss of tissue-resident decidual macrophages, and upregulated cytokine/chemokine signaling in monocyte-derived decidual macrophages. Furthermore, we describe increased frequencies of activated tissue-resident T cells and decreased abundance of regulatory T cells with infection while frequencies of cytotoxic CD4/CD8 T cells are increased in the blood. In contrast to decidual macrophages, type I IFN signaling is higher in decidual T cells. Finally, infection leads to a narrowing of T cell receptor diversity in both blood and decidua. Collectively, these observations indicate that asymptomatic/mild COVID-19 during pregnancy results in remodeling of the immunological landscape of the maternal-fetal interface, with a potential for long-term adverse outcomes for the offspring.
Keywords: COVID-19; CP: Immunology; CP: Microbiology; SARS-CoV-2; T cells; TCR; decidua; macrophages; placenta; pregnancy.