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Cell . The origins of SARS-CoV-2: A critical review

tetano

Editor, Senior Moderator
Cell


. 2021 Aug 19;S0092-8674(21)00991-0.
doi: 10.1016/j.cell.2021.08.017. Online ahead of print.
The origins of SARS-CoV-2: A critical review


Edward C Holmes[SUP] 1 [/SUP], Stephen A Goldstein[SUP] 2 [/SUP], Angela L Rasmussen[SUP] 3 [/SUP], David L Robertson[SUP] 4 [/SUP], Alexander Crits-Christoph[SUP] 5 [/SUP], Joel O Wertheim[SUP] 6 [/SUP], Simon J Anthony[SUP] 7 [/SUP], Wendy S Barclay[SUP] 8 [/SUP], Maciej F Boni[SUP] 9 [/SUP], Peter C Doherty[SUP] 10 [/SUP], Jeremy Farrar[SUP] 11 [/SUP], Jemma L Geoghegan[SUP] 12 [/SUP], Xiaowei Jiang[SUP] 13 [/SUP], Julian L Leibowitz[SUP] 14 [/SUP], Stuart J D Neil[SUP] 15 [/SUP], Tim Skern[SUP] 16 [/SUP], Susan R Weiss[SUP] 17 [/SUP], Michael Worobey[SUP] 18 [/SUP], Kristian G Andersen[SUP] 19 [/SUP], Robert F Garry[SUP] 20 [/SUP], Andrew Rambaut[SUP] 21 [/SUP]



Affiliations

Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a "laboratory escape" scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Keywords: COVID-19; SARS-CoV-2; evolution; origins; zoonosis.
 
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