tetano
Editor, Senior Moderator
PLoS One. 2014 Jul 24;9(7):e103149. doi: 10.1371/journal.pone.0103149. eCollection 2014.
Cellular Changes in Blood Indicate Severe Respiratory Disease during Influenza Infections in Mice.
Dengler L1, K?hn N1, Shin DL1, Hatesuer B1, Schughart K2, Wilk E1.
Author information
Abstract
Influenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mouse is a valuable model system enabling us to study the local inflammatory host response and the influence on blood parameters under controlled circumstances. Here, we compared the lung and peripheral changes after PR8 (H1N1) influenza A virus infection in C57BL/6J and DBA/2J mice using virus variants of different pathogenicity resulting in non-lethal and lethal disease. We monitored hematological and immunological parameters revealing that the granulocyte to lymphocyte ratio in the blood represents an early indicator of severe disease progression already two days after influenza A infection in mice. These findings might be relevant to optimize early diagnostic options of severe influenza disease and to monitor successful therapeutic treatment in humans.
PMID:
25058639
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25058639
Cellular Changes in Blood Indicate Severe Respiratory Disease during Influenza Infections in Mice.
Dengler L1, K?hn N1, Shin DL1, Hatesuer B1, Schughart K2, Wilk E1.
Author information
Abstract
Influenza A infection is a serious threat to human and animal health. Many of the biological mechanisms of the host-pathogen-interactions are still not well understood and reliable biomarkers indicating the course of the disease are missing. The mouse is a valuable model system enabling us to study the local inflammatory host response and the influence on blood parameters under controlled circumstances. Here, we compared the lung and peripheral changes after PR8 (H1N1) influenza A virus infection in C57BL/6J and DBA/2J mice using virus variants of different pathogenicity resulting in non-lethal and lethal disease. We monitored hematological and immunological parameters revealing that the granulocyte to lymphocyte ratio in the blood represents an early indicator of severe disease progression already two days after influenza A infection in mice. These findings might be relevant to optimize early diagnostic options of severe influenza disease and to monitor successful therapeutic treatment in humans.
PMID:
25058639
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/25058639