tetano
Editor, Senior Moderator
Arch Virol. 2017 Oct 31. doi: 10.1007/s00705-017-3603-y. [Epub ahead of print]
[h=1]Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015.[/h] Moasser E[SUP]1[/SUP], Behzadian F[SUP]1[/SUP], Moattari A[SUP]2[/SUP], Fotouhi F[SUP]3[/SUP], Zaraket H[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) expressed by influenza A/H1N1pdm09 and A/H3N2 viruses circulating in Iran from 2010 to 2015.
[h=4]METHODS:[/h] We genetically analyzed the NAs of 38 influenza A/H1N1pdm09 and 35 A/H3N2 isolates.
[h=4]RESULTS:[/h] The Iranian A/H1N1pdm09 viruses belonged to seven genogroups/subgenogroups, with the dominant groups being genogroups 6B and 6C. The A/H3N2 isolates fell into six gneogroups/subgenogroups, with the dominant genogroups being 3C and 3C.2a. The most common mutations detected among the A/H1N1pdm09 viruses included N44S, V106I, N200S, and N248D. All H1N1pdm09 viruses were genetically susceptible to the NAIs. However, one A/H1N1pdm09 virus from the 2013-2014 season possessed an NA-S247N mutation, which reduces the susceptibility to oseltamivir. In case of H3N2, none of the analyzed Iranian strains carried a substitution that might affect its susceptibility to NAIs.
[h=4]CONCLUSION:[/h] The ongoing evolution of influenza viruses and the detect of influenza viruses with reduced susceptibility to NAIs warrants continuous monitoring of the circulating strains.
[h=4]KEYWORDS:[/h] A/H1N1pdm09; A/H3N2; Antiviral resistance; Influenza; Iran; Molecular genetic analysis
PMID: 29086107 DOI: 10.1007/s00705-017-3603-y
[h=1]Characterization of the neuraminidase genes from human influenza A viruses circulating in Iran from 2010 to 2015.[/h] Moasser E[SUP]1[/SUP], Behzadian F[SUP]1[/SUP], Moattari A[SUP]2[/SUP], Fotouhi F[SUP]3[/SUP], Zaraket H[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Characterization of influenza viruses is critical for detection of new emerging variants. Herein, we analyzed the genetic diversity and drug susceptibility of the neuraminidase gene (NAs) expressed by influenza A/H1N1pdm09 and A/H3N2 viruses circulating in Iran from 2010 to 2015.
[h=4]METHODS:[/h] We genetically analyzed the NAs of 38 influenza A/H1N1pdm09 and 35 A/H3N2 isolates.
[h=4]RESULTS:[/h] The Iranian A/H1N1pdm09 viruses belonged to seven genogroups/subgenogroups, with the dominant groups being genogroups 6B and 6C. The A/H3N2 isolates fell into six gneogroups/subgenogroups, with the dominant genogroups being 3C and 3C.2a. The most common mutations detected among the A/H1N1pdm09 viruses included N44S, V106I, N200S, and N248D. All H1N1pdm09 viruses were genetically susceptible to the NAIs. However, one A/H1N1pdm09 virus from the 2013-2014 season possessed an NA-S247N mutation, which reduces the susceptibility to oseltamivir. In case of H3N2, none of the analyzed Iranian strains carried a substitution that might affect its susceptibility to NAIs.
[h=4]CONCLUSION:[/h] The ongoing evolution of influenza viruses and the detect of influenza viruses with reduced susceptibility to NAIs warrants continuous monitoring of the circulating strains.
[h=4]KEYWORDS:[/h] A/H1N1pdm09; A/H3N2; Antiviral resistance; Influenza; Iran; Molecular genetic analysis
PMID: 29086107 DOI: 10.1007/s00705-017-3603-y