tetano
Editor, Senior Moderator
Clin Chim Acta
. 2020 Jun 5;S0009-8981(20)30273-4.
doi: 10.1016/j.cca.2020.06.009. Online ahead of print.
Comparative Analysis of Laboratory Indexes of Severe and Non-Severe Patients Infected With COVID-19
Jingfeng Bao[SUP] 1 [/SUP], Chenxi Li[SUP] 1 [/SUP], Kai Zhang[SUP] 2 [/SUP], Haiquan Kang[SUP] 3 [/SUP], Wensen Chen[SUP] 4 [/SUP], Bing Gu[SUP] 5 [/SUP]
Affiliations
Abstract
Background: The pandemic coronavirus disease 2019 (COVID-19) has threaten the global health. The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. We found indicators that may most effectively predict a non-severe COVID-19 patient develop into a severe patient.
Methods: We conducted a meta-analysis to compare the laboratory findings of severe patients with non-severe patients with COVID-19 from searched articles.
Results: Through the analysis of laboratory examination information of patients with COVID-19 from 35 articles (5912 patients), we demonstrated that severe cases possessed higher levels of leukocyte (1.20-fold), neutrophil (1.33-fold), CRP (3.04-fold), PCT (2.00-fold), ESR (1.44-fold), AST (1.40-fold), ALT (1.34-fold), LDH (1.54-fold), CK (1.44-fold), CK-MB (1.39-fold), total bilirubin(1.14-fold), urea (1.28-fold), creatine (1.09-fold), PT (1.03-fold) and D-dimer (2.74-fold), as well as lower levels of lymphocytes (1.44-fold), eosinophil (2.00-fold), monocyte (1.08-fold), Hemoglobin (1.53-fold), PLT (1.15-fold), albumin (1.15-fold), and APTT (1.02-fold). Lymphocyte subsets and series of inflammatory cytokines were also different in severe cases with the non-severe ones, including lower levels of CD4 T cells (2.10-fold) and CD8 T cells (2.00-fold), higher levels of IL-1β (1.02-fold), IL-6 (1.93-fold) and IL-10 (1.55-fold).
Conclusions: Some certain laboratory inspections could predict the progress of the COVID-19 changes, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease.
Keywords: COVID-19; laboratory findings; meta-analysis; prognosis.
. 2020 Jun 5;S0009-8981(20)30273-4.
doi: 10.1016/j.cca.2020.06.009. Online ahead of print.
Comparative Analysis of Laboratory Indexes of Severe and Non-Severe Patients Infected With COVID-19
Jingfeng Bao[SUP] 1 [/SUP], Chenxi Li[SUP] 1 [/SUP], Kai Zhang[SUP] 2 [/SUP], Haiquan Kang[SUP] 3 [/SUP], Wensen Chen[SUP] 4 [/SUP], Bing Gu[SUP] 5 [/SUP]
Affiliations
- PMID: 32511971
- PMCID: PMC7274996
- DOI: 10.1016/j.cca.2020.06.009
Abstract
Background: The pandemic coronavirus disease 2019 (COVID-19) has threaten the global health. The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. We found indicators that may most effectively predict a non-severe COVID-19 patient develop into a severe patient.
Methods: We conducted a meta-analysis to compare the laboratory findings of severe patients with non-severe patients with COVID-19 from searched articles.
Results: Through the analysis of laboratory examination information of patients with COVID-19 from 35 articles (5912 patients), we demonstrated that severe cases possessed higher levels of leukocyte (1.20-fold), neutrophil (1.33-fold), CRP (3.04-fold), PCT (2.00-fold), ESR (1.44-fold), AST (1.40-fold), ALT (1.34-fold), LDH (1.54-fold), CK (1.44-fold), CK-MB (1.39-fold), total bilirubin(1.14-fold), urea (1.28-fold), creatine (1.09-fold), PT (1.03-fold) and D-dimer (2.74-fold), as well as lower levels of lymphocytes (1.44-fold), eosinophil (2.00-fold), monocyte (1.08-fold), Hemoglobin (1.53-fold), PLT (1.15-fold), albumin (1.15-fold), and APTT (1.02-fold). Lymphocyte subsets and series of inflammatory cytokines were also different in severe cases with the non-severe ones, including lower levels of CD4 T cells (2.10-fold) and CD8 T cells (2.00-fold), higher levels of IL-1β (1.02-fold), IL-6 (1.93-fold) and IL-10 (1.55-fold).
Conclusions: Some certain laboratory inspections could predict the progress of the COVID-19 changes, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease.
Keywords: COVID-19; laboratory findings; meta-analysis; prognosis.