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Clin Infect Dis . Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection

tetano

Editor, Senior Moderator
Clin Infect Dis


. 2020 Dec 3;ciaa1803.
doi: 10.1093/cid/ciaa1803. Online ahead of print.
Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection


Daniel Poston[SUP] 1 2 [/SUP], Yiska Weisblum[SUP] 1 [/SUP], Helen Wise[SUP] 3 [/SUP], Kate Templeton[SUP] 3 [/SUP], Sara Jenks[SUP] 3 [/SUP], Theodora Hatziioannou[SUP] 1 [/SUP], Paul Bieniasz[SUP] 1 4 [/SUP]



Affiliations

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Keywords: COVID19; SARS-CoV-2; Seasonal coronavirus; antibodies; neutralization.
 
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