tetano
Editor, Senior Moderator
Clin Infect Dis
. 2020 May 15;ciaa577.
doi: 10.1093/cid/ciaa577. Online ahead of print.
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in COVID-19
Veronica Bordoni[SUP] 1 [/SUP], Alessandra Sacchi[SUP] 1 [/SUP], Eleonora Cimini[SUP] 1 [/SUP], Stefania Notari[SUP] 1 [/SUP], Germana Grassi[SUP] 1 [/SUP], Eleonora Tartaglia[SUP] 1 [/SUP], Rita Casetti[SUP] 1 [/SUP], Letizia Giancola[SUP] 1 [/SUP], Nazario Bevilacqua[SUP] 1 [/SUP], Markus Maeurer[SUP] 2 3 [/SUP], Alimuddin Zumla[SUP] 4 [/SUP], Franco Locatelli[SUP] 5 [/SUP], Fabrizio De Benedetti[SUP] 5 [/SUP], Fabrizio Palmieri[SUP] 1 [/SUP], Luisa Marchioni[SUP] 1 [/SUP], Maria R Capobianchi[SUP] 1 [/SUP], Gianpiero D'Offizi[SUP] 1 [/SUP], Nicola Petrosillo[SUP] 1 [/SUP], Andrea Antinori[SUP] 1 [/SUP], Emanuele Nicastri[SUP] 1 [/SUP], Giuseppe Ippolito[SUP] 1 [/SUP], Chiara Agrati[SUP] 1 [/SUP]
Affiliations
Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occur in COVID-19 patients. These inversely correlated with perforin-expressing NK and CD3+T-cells. We observed a lower perforin+ NK cells number in intensive care unit (ICU) compared to non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
Keywords: COVID-19; Inflammation; MDSC; NK cells; cytotoxic cells.
. 2020 May 15;ciaa577.
doi: 10.1093/cid/ciaa577. Online ahead of print.
An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in COVID-19
Veronica Bordoni[SUP] 1 [/SUP], Alessandra Sacchi[SUP] 1 [/SUP], Eleonora Cimini[SUP] 1 [/SUP], Stefania Notari[SUP] 1 [/SUP], Germana Grassi[SUP] 1 [/SUP], Eleonora Tartaglia[SUP] 1 [/SUP], Rita Casetti[SUP] 1 [/SUP], Letizia Giancola[SUP] 1 [/SUP], Nazario Bevilacqua[SUP] 1 [/SUP], Markus Maeurer[SUP] 2 3 [/SUP], Alimuddin Zumla[SUP] 4 [/SUP], Franco Locatelli[SUP] 5 [/SUP], Fabrizio De Benedetti[SUP] 5 [/SUP], Fabrizio Palmieri[SUP] 1 [/SUP], Luisa Marchioni[SUP] 1 [/SUP], Maria R Capobianchi[SUP] 1 [/SUP], Gianpiero D'Offizi[SUP] 1 [/SUP], Nicola Petrosillo[SUP] 1 [/SUP], Andrea Antinori[SUP] 1 [/SUP], Emanuele Nicastri[SUP] 1 [/SUP], Giuseppe Ippolito[SUP] 1 [/SUP], Chiara Agrati[SUP] 1 [/SUP]
Affiliations
- PMID: 32407466
- PMCID: PMC7239202
- DOI: 10.1093/cid/ciaa577
Abstract
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occur in COVID-19 patients. These inversely correlated with perforin-expressing NK and CD3+T-cells. We observed a lower perforin+ NK cells number in intensive care unit (ICU) compared to non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
Keywords: COVID-19; Inflammation; MDSC; NK cells; cytotoxic cells.