tetano
Editor, Senior Moderator
Clin Infect Dis
. 2021 Nov 19;ciab963.
doi: 10.1093/cid/ciab963. Online ahead of print.
Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination
David H Canaday[SUP] 1 2 [/SUP], Oladayo A Oyebanji[SUP] 1 [/SUP], Debbie Keresztesy[SUP] 1 [/SUP], Michael Payne[SUP] 1 [/SUP], Dennis Wilk[SUP] 1 [/SUP], Lenore Carias[SUP] 1 [/SUP], Htin Aung[SUP] 1 [/SUP], Kerri St Denis[SUP] 3 [/SUP], Evan C Lam[SUP] 3 [/SUP], Christopher F Rowley[SUP] 4 [/SUP], Sarah D Berry[SUP] 5 [/SUP], Cheryl M Cameron[SUP] 1 [/SUP], Mark J Cameron[SUP] 1 [/SUP], Brigid M Wilson[SUP] 2 [/SUP], Alejandro B Balazs[SUP] 3 [/SUP], Christopher L King[SUP] 1 [/SUP], Stefan Gravenstein[SUP] 6 7 [/SUP]
Affiliations
Abstract
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.
Keywords: COVID-19; antibody; long-term care; vaccine.
. 2021 Nov 19;ciab963.
doi: 10.1093/cid/ciab963. Online ahead of print.
Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination
David H Canaday[SUP] 1 2 [/SUP], Oladayo A Oyebanji[SUP] 1 [/SUP], Debbie Keresztesy[SUP] 1 [/SUP], Michael Payne[SUP] 1 [/SUP], Dennis Wilk[SUP] 1 [/SUP], Lenore Carias[SUP] 1 [/SUP], Htin Aung[SUP] 1 [/SUP], Kerri St Denis[SUP] 3 [/SUP], Evan C Lam[SUP] 3 [/SUP], Christopher F Rowley[SUP] 4 [/SUP], Sarah D Berry[SUP] 5 [/SUP], Cheryl M Cameron[SUP] 1 [/SUP], Mark J Cameron[SUP] 1 [/SUP], Brigid M Wilson[SUP] 2 [/SUP], Alejandro B Balazs[SUP] 3 [/SUP], Christopher L King[SUP] 1 [/SUP], Stefan Gravenstein[SUP] 6 7 [/SUP]
Affiliations
- PMID: 35174389
- DOI: 10.1093/cid/ciab963
Abstract
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.
Keywords: COVID-19; antibody; long-term care; vaccine.