tetano
Editor, Senior Moderator
Clin Kidney J
. 2020 Jun 4;13(3):291-296.
doi: 10.1093/ckj/sfaa082. eCollection 2020 Jun.
A brand-new cardiorenal syndrome in the COVID-19 setting
Mugurel Apetrii[SUP] 1 2 [/SUP], Stefana Enache[SUP] 3 [/SUP], Dimitrie Siriopol[SUP] 1 2 [/SUP], Alexandru Burlacu[SUP] 2 4 [/SUP], Asiye Kanbay[SUP] 5 [/SUP], Mehmet Kanbay[SUP] 6 [/SUP], Dragos Scripcariu[SUP] 2 7 [/SUP], Adrian Covic[SUP] 1 2 [/SUP]
Affiliations
Abstract
Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient's lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.
Keywords: ACE2; CKD; COVID-19; cardiorenal syndrome; myocardial injury.
. 2020 Jun 4;13(3):291-296.
doi: 10.1093/ckj/sfaa082. eCollection 2020 Jun.
A brand-new cardiorenal syndrome in the COVID-19 setting
Mugurel Apetrii[SUP] 1 2 [/SUP], Stefana Enache[SUP] 3 [/SUP], Dimitrie Siriopol[SUP] 1 2 [/SUP], Alexandru Burlacu[SUP] 2 4 [/SUP], Asiye Kanbay[SUP] 5 [/SUP], Mehmet Kanbay[SUP] 6 [/SUP], Dragos Scripcariu[SUP] 2 7 [/SUP], Adrian Covic[SUP] 1 2 [/SUP]
Affiliations
- PMID: 32695320
- PMCID: PMC7314230
- DOI: 10.1093/ckj/sfaa082
Abstract
Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient's lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.
Keywords: ACE2; CKD; COVID-19; cardiorenal syndrome; myocardial injury.