tetano
Editor, Senior Moderator
Clin Med Insights Case Rep
. 2020 Dec 8;13:1179547620980381.
doi: 10.1177/1179547620980381. eCollection 2020.
SARS-CoV-2 and Anti-Cardiolipin Antibodies
Mazen Jizzini[SUP] 1 [/SUP], Mohsin Shah[SUP] 2 [/SUP], Kehua Zhou[SUP] 1 [/SUP]
Affiliations
Abstract
The current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically ill patients with SARS-CoV-2 is now well reported. We discuss a recent case of COVID-19 with concurrent acute pulmonary embolism and a positive cardiolipin antibody (IgM). The presence of antiphospholipid antibodies is key to diagnosing antiphospholipid syndrome (APS). However, their presence can be transient or persistent after viral infections. Serial inflammatory markers in conjunction with anti-phospholipid antibody testing is critical for the diagnosis of APS in this emerging patient population. Our case report reviews details suggestive of APS in the setting of SARS-CoV-2 and aims to provide clinical diagnostic clues that could help warrant further workup and assist with management strategies.
Keywords: SARS-CoV-2; anticardiolipin; antiphospholipid syndrome; coagulopathy; coronavirus; covid-19; critical care; hematology; pulmonary embolism; thrombosis.
. 2020 Dec 8;13:1179547620980381.
doi: 10.1177/1179547620980381. eCollection 2020.
SARS-CoV-2 and Anti-Cardiolipin Antibodies
Mazen Jizzini[SUP] 1 [/SUP], Mohsin Shah[SUP] 2 [/SUP], Kehua Zhou[SUP] 1 [/SUP]
Affiliations
- PMID: 33343204
- PMCID: PMC7727046
- DOI: 10.1177/1179547620980381
Abstract
The current COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to distinct diagnostic and management challenges for front-line healthcare workers. The risk of excessive coagulation activation leading to a cascade of thrombotic events in critically ill patients with SARS-CoV-2 is now well reported. We discuss a recent case of COVID-19 with concurrent acute pulmonary embolism and a positive cardiolipin antibody (IgM). The presence of antiphospholipid antibodies is key to diagnosing antiphospholipid syndrome (APS). However, their presence can be transient or persistent after viral infections. Serial inflammatory markers in conjunction with anti-phospholipid antibody testing is critical for the diagnosis of APS in this emerging patient population. Our case report reviews details suggestive of APS in the setting of SARS-CoV-2 and aims to provide clinical diagnostic clues that could help warrant further workup and assist with management strategies.
Keywords: SARS-CoV-2; anticardiolipin; antiphospholipid syndrome; coagulopathy; coronavirus; covid-19; critical care; hematology; pulmonary embolism; thrombosis.