tetano
Editor, Senior Moderator
Clin Rheumatol
. 2021 Jan 2.
doi: 10.1007/s10067-020-05534-1. Online ahead of print.
Kawasaki disease and influenza-new lessons from old associations
Aaqib Zaffar Banday[SUP] 1 [/SUP], Ashwini Arul[SUP] 1 [/SUP], Pandiarajan Vignesh[SUP] 2 [/SUP], Mini P Singh[SUP] 3 [/SUP], Kapil Goyal[SUP] 3 [/SUP], Surjit Singh[SUP] 1 [/SUP]
Affiliations
Abstract
Kawasaki disease (KD), an enigmatic medium vessel vasculitis, presents as an acute febrile illness predominantly affecting young children. KD appears to be a hyper-inflammatory response elicited by environmental or infectious agents (including respiratory viruses) in genetically predisposed individuals. Numerous reports from the current era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have described the occurrence of KD/KD-like illness in close temporal proximity to SARS-CoV-2 infection or exposure. Notably, KD has been reported in association with H[SUB]1[/SUB]N[SUB]1[/SUB]-pdm09 virus that caused the previous pandemic a decade ago. Non-H[SUB]1[/SUB]N[SUB]1[/SUB] influenza infections as well as influenza vaccination have also been reported to trigger KD. Herein, we report a case of H[SUB]1[/SUB]N[SUB]1[/SUB]-pdm09 influenza who developed KD. We review the published literature on influenza infection or vaccination triggering KD. This may help in a better understanding of the KD/KD-like illness associated with SARS-CoV-2. Besides, we also evaluate the safety of aspirin in influenza-triggered KD as aspirin administration in children with influenza is associated with the risk of development of Reye syndrome.
Keywords: Aspirin; COVID-19; Coronavirus; Influenza; Kawasaki disease; SARS-CoV-2; Vaccine.
. 2021 Jan 2.
doi: 10.1007/s10067-020-05534-1. Online ahead of print.
Kawasaki disease and influenza-new lessons from old associations
Aaqib Zaffar Banday[SUP] 1 [/SUP], Ashwini Arul[SUP] 1 [/SUP], Pandiarajan Vignesh[SUP] 2 [/SUP], Mini P Singh[SUP] 3 [/SUP], Kapil Goyal[SUP] 3 [/SUP], Surjit Singh[SUP] 1 [/SUP]
Affiliations
- PMID: 33387094
- PMCID: PMC7778392
- DOI: 10.1007/s10067-020-05534-1
Abstract
Kawasaki disease (KD), an enigmatic medium vessel vasculitis, presents as an acute febrile illness predominantly affecting young children. KD appears to be a hyper-inflammatory response elicited by environmental or infectious agents (including respiratory viruses) in genetically predisposed individuals. Numerous reports from the current era of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have described the occurrence of KD/KD-like illness in close temporal proximity to SARS-CoV-2 infection or exposure. Notably, KD has been reported in association with H[SUB]1[/SUB]N[SUB]1[/SUB]-pdm09 virus that caused the previous pandemic a decade ago. Non-H[SUB]1[/SUB]N[SUB]1[/SUB] influenza infections as well as influenza vaccination have also been reported to trigger KD. Herein, we report a case of H[SUB]1[/SUB]N[SUB]1[/SUB]-pdm09 influenza who developed KD. We review the published literature on influenza infection or vaccination triggering KD. This may help in a better understanding of the KD/KD-like illness associated with SARS-CoV-2. Besides, we also evaluate the safety of aspirin in influenza-triggered KD as aspirin administration in children with influenza is associated with the risk of development of Reye syndrome.
Keywords: Aspirin; COVID-19; Coronavirus; Influenza; Kawasaki disease; SARS-CoV-2; Vaccine.