tetano
Editor, Senior Moderator
Clin Transl Immunology
. 2020 Nov 13;9(11):e1204.
doi: 10.1002/cti2.1204. eCollection 2020.
Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19
Julika Neumann[SUP] 1 2 [/SUP], Teresa Prezzemolo[SUP] 1 2 [/SUP], Lore Vanderbeke[SUP] 2 3 [/SUP], Carlos P Roca[SUP] 4 [/SUP], Margaux Gerbaux[SUP] 2 5 [/SUP], Silke Janssens[SUP] 1 2 [/SUP], Mathijs Willemsen[SUP] 1 2 [/SUP], Oliver Burton[SUP] 4 [/SUP], Pierre Van Mol[SUP] 3 6 [/SUP], Yannick Van Herck[SUP] 3 [/SUP], CONTAGIOUS co‐authors; Joost Wauters[SUP] 3 [/SUP], Els Wauters[SUP] 3 [/SUP], Adrian Liston[SUP] 1 2 4 [/SUP], Stephanie Humblet-Baron[SUP] 2 [/SUP]
Collaborators, Affiliations
Abstract
Objectives: The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation.
Methods: Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients.
Results: We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than hyper-immune activation. Unique to the severe COVID-19 cases was a large increase in the proportion of IL-10-secreting regulatory T cells, a lineage known to possess anti-inflammatory properties in the lung.
Conclusion: As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates as a systems immunology resource for the COVID-19 research community.
Keywords: COVID‐19; IL‐10; SARS‐CoV‐2; T regulatory cells; open resource; systems immunology.
. 2020 Nov 13;9(11):e1204.
doi: 10.1002/cti2.1204. eCollection 2020.
Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19
Julika Neumann[SUP] 1 2 [/SUP], Teresa Prezzemolo[SUP] 1 2 [/SUP], Lore Vanderbeke[SUP] 2 3 [/SUP], Carlos P Roca[SUP] 4 [/SUP], Margaux Gerbaux[SUP] 2 5 [/SUP], Silke Janssens[SUP] 1 2 [/SUP], Mathijs Willemsen[SUP] 1 2 [/SUP], Oliver Burton[SUP] 4 [/SUP], Pierre Van Mol[SUP] 3 6 [/SUP], Yannick Van Herck[SUP] 3 [/SUP], CONTAGIOUS co‐authors; Joost Wauters[SUP] 3 [/SUP], Els Wauters[SUP] 3 [/SUP], Adrian Liston[SUP] 1 2 4 [/SUP], Stephanie Humblet-Baron[SUP] 2 [/SUP]
Collaborators, Affiliations
- PMID: 33209300
- PMCID: PMC7662088
- DOI: 10.1002/cti2.1204
Abstract
Objectives: The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation.
Methods: Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients.
Results: We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than hyper-immune activation. Unique to the severe COVID-19 cases was a large increase in the proportion of IL-10-secreting regulatory T cells, a lineage known to possess anti-inflammatory properties in the lung.
Conclusion: As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates as a systems immunology resource for the COVID-19 research community.
Keywords: COVID‐19; IL‐10; SARS‐CoV‐2; T regulatory cells; open resource; systems immunology.