tetano
Editor, Senior Moderator
Clin Transplant Res
. 2024 Dec 31;38(4):247-256.
doi: 10.4285/ctr.24.0062. SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients
Euri Seo[SUP] 1 [/SUP], Eui-Cheol Shin[SUP] 1 2 [/SUP], Min Kyung Jung[SUP] 1 [/SUP]
Affiliations
Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include humoral and cellular immune responses. Most studies on the SARS-CoV-2 vaccine have focused primarily on humoral immunity, but cellular immunity is vital for effectively controlling progression to severe COVID-19. In SOTRs, the vaccine-induced adaptive immune response is significantly attenuated compared to the response in healthy individuals. Nevertheless, vaccinated SOTRs exhibit a reduced rate and severity of SARS-CoV-2 infection. This review aims to provide a concise overview of the current understanding of SARS-CoV-2 vaccine-induced immune responses in SOTRs.
Keywords: Cellular immune responses; Humoral immune responses; SARS-CoV-2 vaccine; Solid organ transplant recipients.
. 2024 Dec 31;38(4):247-256.
doi: 10.4285/ctr.24.0062. SARS-CoV-2 vaccine-elicited immune responses in solid organ transplant recipients
Euri Seo[SUP] 1 [/SUP], Eui-Cheol Shin[SUP] 1 2 [/SUP], Min Kyung Jung[SUP] 1 [/SUP]
Affiliations
- PMID: 39743229
- DOI: 10.4285/ctr.24.0062
Solid organ transplant recipients (SOTRs) are considered a high-risk group for coronavirus disease 2019 (COVID-19). The adaptive immune responses generated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination include humoral and cellular immune responses. Most studies on the SARS-CoV-2 vaccine have focused primarily on humoral immunity, but cellular immunity is vital for effectively controlling progression to severe COVID-19. In SOTRs, the vaccine-induced adaptive immune response is significantly attenuated compared to the response in healthy individuals. Nevertheless, vaccinated SOTRs exhibit a reduced rate and severity of SARS-CoV-2 infection. This review aims to provide a concise overview of the current understanding of SARS-CoV-2 vaccine-induced immune responses in SOTRs.
Keywords: Cellular immune responses; Humoral immune responses; SARS-CoV-2 vaccine; Solid organ transplant recipients.