tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2015 Jul 15. [Epub ahead of print]
[h=1]ComparativeBurden of Influenza A/H1N1, A/H3N2, and B Infections in ChildrenTreated as Outpatients.[/h] Silvennoinen H[SUP]1[/SUP], Huusko T, Vuorinen T, Heikkinen T.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Few studies have directly compared the clinical impact of different types and subtypes of influenza viruses in children.
[h=4]METHODS:[/h] In a prospective study of respiratory infections in pre-enrolled cohorts of children ≤13 years of age, we compared the clinical features and the overall burden of illness between outpatient children with A/H1N1, A/H3N2, and B infections. The data were derived from structured medical records filled out by study physicians and from daily symptom diaries filled out by the parents throughout the follow-up period.
[h=4]RESULTS:[/h] Of 358 children included in the analyses, 203 (57%) had influenza A/H1N1, 96 (27%) had A/H3N2, and 59 (16%) had influenza B infection. Children with influenza A/H3N2 were significantly younger (median, 3.2 years) than those with A/H1N1 (median, 4.8 years) or B (median, 5.1 years) infections (P<0.0001). When adjusted for age, children 3-6 years of age with A/H3N2 infection had a higher frequency of fever ≥39.0C (67% vs 38%; P=0.002), longer duration of fever (median, 4 vs 3 days; P=0.02), and more antibiotic treatments (43% vs 20%; P=0.004) than did children with A/H1N1 infections. Overall, the clinical presentation, duration of illness, frequency of complications, children?s absenteeism from day care or school, and parental work absenteeism were comparable between children with A/H1N1, A/H3N2, and B infections.
[h=4]CONCLUSIONS:[/h] Adjusted for age, the clinical manifestations and the burden of illness are largely comparable between children with influenza A/H1N1, A/H3N2, and B infections.
PMID: 26181897 [PubMed - as supplied by publisher]
[h=1]ComparativeBurden of Influenza A/H1N1, A/H3N2, and B Infections in ChildrenTreated as Outpatients.[/h] Silvennoinen H[SUP]1[/SUP], Huusko T, Vuorinen T, Heikkinen T.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Few studies have directly compared the clinical impact of different types and subtypes of influenza viruses in children.
[h=4]METHODS:[/h] In a prospective study of respiratory infections in pre-enrolled cohorts of children ≤13 years of age, we compared the clinical features and the overall burden of illness between outpatient children with A/H1N1, A/H3N2, and B infections. The data were derived from structured medical records filled out by study physicians and from daily symptom diaries filled out by the parents throughout the follow-up period.
[h=4]RESULTS:[/h] Of 358 children included in the analyses, 203 (57%) had influenza A/H1N1, 96 (27%) had A/H3N2, and 59 (16%) had influenza B infection. Children with influenza A/H3N2 were significantly younger (median, 3.2 years) than those with A/H1N1 (median, 4.8 years) or B (median, 5.1 years) infections (P<0.0001). When adjusted for age, children 3-6 years of age with A/H3N2 infection had a higher frequency of fever ≥39.0C (67% vs 38%; P=0.002), longer duration of fever (median, 4 vs 3 days; P=0.02), and more antibiotic treatments (43% vs 20%; P=0.004) than did children with A/H1N1 infections. Overall, the clinical presentation, duration of illness, frequency of complications, children?s absenteeism from day care or school, and parental work absenteeism were comparable between children with A/H1N1, A/H3N2, and B infections.
[h=4]CONCLUSIONS:[/h] Adjusted for age, the clinical manifestations and the burden of illness are largely comparable between children with influenza A/H1N1, A/H3N2, and B infections.
PMID: 26181897 [PubMed - as supplied by publisher]