tetano
Editor, Senior Moderator
J Infect Dis. 2012 May 4. [Epub ahead of print]
Critical role of NK cells in lung immunopathology during influenza infection in mice.
Abdul-Careem MF, Mian MF, Yue G, Gillgrass A, Chenoweth MJ, Barra NG, Chew MV, Chan T, Al-Garawi AA, Jordana M, Ashkar AA.
Source
Center for Gene Therapeutics and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
Abstract
Influenza viral infection results in excessive pulmonary inflammation that has been linked to the damage caused by immune responses and viral replication. The multi-functional cytokine, Interleukin (IL)-15, influences the proliferation and maintenance of immune cells such as CD8+ T cells and NK cells. Here we show that IL-15(-/-) mice are protected from lethal influenza infection. Irrespective of the mouse strains, the protection observed was linked to the lack of NK cells. Increased survival in the IL-15(-/-) or NK cell depleted wild-type mice was associated with significantly lower lung lesions, as well as decreased mononuclear cells and neutrophils in the airway lumen. Levels of IL-10 were significantly higher and pro-inflammatory cytokines including IL-6 and IL-12 were significantly lower in the bronchoalveolar-lavage fluid from IL-15(-/-) and NK cell depleted wild-type mice compared to control mice. Our data suggest that NK cells significantly augment pulmonary inflammation contributing to the pathogenesis of influenza infection.
PMID:
22561366
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22561366
Critical role of NK cells in lung immunopathology during influenza infection in mice.
Abdul-Careem MF, Mian MF, Yue G, Gillgrass A, Chenoweth MJ, Barra NG, Chew MV, Chan T, Al-Garawi AA, Jordana M, Ashkar AA.
Source
Center for Gene Therapeutics and Institute for Infectious Diseases Research, Department of Pathology and Molecular Medicine, McMaster University Health Sciences Center, 1280 Main Street West, Hamilton, Ontario, L8S 4K1, Canada.
Abstract
Influenza viral infection results in excessive pulmonary inflammation that has been linked to the damage caused by immune responses and viral replication. The multi-functional cytokine, Interleukin (IL)-15, influences the proliferation and maintenance of immune cells such as CD8+ T cells and NK cells. Here we show that IL-15(-/-) mice are protected from lethal influenza infection. Irrespective of the mouse strains, the protection observed was linked to the lack of NK cells. Increased survival in the IL-15(-/-) or NK cell depleted wild-type mice was associated with significantly lower lung lesions, as well as decreased mononuclear cells and neutrophils in the airway lumen. Levels of IL-10 were significantly higher and pro-inflammatory cytokines including IL-6 and IL-12 were significantly lower in the bronchoalveolar-lavage fluid from IL-15(-/-) and NK cell depleted wild-type mice compared to control mice. Our data suggest that NK cells significantly augment pulmonary inflammation contributing to the pathogenesis of influenza infection.
PMID:
22561366
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22561366