tetano
Editor, Senior Moderator
Curr Med Sci
. 2021 Feb;41(1):51-57.
doi: 10.1007/s11596-021-2317-2. Epub 2021 Feb 13.
Co-infection of SARS-COV-2 and Influenza A Virus: A Case Series and Fast Review
Xuan Xiang[SUP] 1 [/SUP], Zi-Hao Wang[SUP] 1 [/SUP], Lin-Lin Ye[SUP] 1 [/SUP], Xin-Liang He[SUP] 1 [/SUP], Xiao-Shan Wei[SUP] 1 [/SUP], Yan-Ling Ma[SUP] 1 [/SUP], Hui Li[SUP] 1 [/SUP], Long Chen[SUP] 1 [/SUP], Xiao-Rong Wang[SUP] 1 [/SUP], Qiong Zhou[SUP] 2 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) occurs in the influenza season and has become a global pandemic. The present study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with influenza A virus (IAV) in an attempt to provide clues for the antiviral interventions of co-infected patients. We described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital, China. In addition, we performed a review in PubMed, Web of Science and CNKI (from January 1 up to November 1, 2020) with combinations of the following key words: "COVID-19, SARS-COV-2, influenza A and co-infection". A total of 28 co-infected patients were enrolled in the analysis. Of the 28 patients, the median age was 54.5 years (IQR, 34.25-67.5) and 14 cases (50.0%) were classified as severe types. The most common symptoms were fever (85.71%), cough (82.14%) and dyspnea (60.71%). Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological changes. The median time from symptom onset to hospital admission was 4 days (IQR, 3-6), and the median time of hospital stay was 14 days (IQR, 8.5-16.75). In conclusion, patients with SARS-COV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological images. SARS-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARS-COV-2 alone.
Keywords: COVID-19; SARS-COV-2; co-infection; influenza A.
. 2021 Feb;41(1):51-57.
doi: 10.1007/s11596-021-2317-2. Epub 2021 Feb 13.
Co-infection of SARS-COV-2 and Influenza A Virus: A Case Series and Fast Review
Xuan Xiang[SUP] 1 [/SUP], Zi-Hao Wang[SUP] 1 [/SUP], Lin-Lin Ye[SUP] 1 [/SUP], Xin-Liang He[SUP] 1 [/SUP], Xiao-Shan Wei[SUP] 1 [/SUP], Yan-Ling Ma[SUP] 1 [/SUP], Hui Li[SUP] 1 [/SUP], Long Chen[SUP] 1 [/SUP], Xiao-Rong Wang[SUP] 1 [/SUP], Qiong Zhou[SUP] 2 [/SUP]
Affiliations
- PMID: 33582905
- DOI: 10.1007/s11596-021-2317-2
Abstract
Coronavirus disease 2019 (COVID-19) occurs in the influenza season and has become a global pandemic. The present study aimed to examine severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) co-infection with influenza A virus (IAV) in an attempt to provide clues for the antiviral interventions of co-infected patients. We described two patients who were co-infected with SARS-CoV-2 and IAV treated at Wuhan Union Hospital, China. In addition, we performed a review in PubMed, Web of Science and CNKI (from January 1 up to November 1, 2020) with combinations of the following key words: "COVID-19, SARS-COV-2, influenza A and co-infection". A total of 28 co-infected patients were enrolled in the analysis. Of the 28 patients, the median age was 54.5 years (IQR, 34.25-67.5) and 14 cases (50.0%) were classified as severe types. The most common symptoms were fever (85.71%), cough (82.14%) and dyspnea (60.71%). Sixteen patients had lymphocytopenia on admission and 23 patients exhibited abnormal radiological changes. The median time from symptom onset to hospital admission was 4 days (IQR, 3-6), and the median time of hospital stay was 14 days (IQR, 8.5-16.75). In conclusion, patients with SARS-COV-2 and IAV co-infection were similar to those infected with SARS-COV-2 alone in symptoms and radiological images. SARS-COV-2 co-infection with IAV could lead to more severe clinical condition but did not experience longer hospital stay compared with patients infected with SARS-COV-2 alone.
Keywords: COVID-19; SARS-COV-2; co-infection; influenza A.