tetano
Editor, Senior Moderator
J Virol. 2019 Feb 13. pii: JVI.02299-18. doi: 10.1128/JVI.02299-18. [Epub ahead of print]
[h=1]Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.[/h] Liu G[SUP]1[/SUP], Zhou Y[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Innate immune sensing of influenza A virus (IAV) requires RIG-I, a fundamental cytoplasmic RNA sensor. How RIG-I's cytoplasmic localization reconciles with the nuclear replication nature of IAV is poorly understood. Recent findings provide advanced insights into the spatiotemporal RIG-I sensing of IAV and highlight the contribution of various RNA ligands to RIG-I activation. Understanding a compartment-specific RIG-I sensing paradigm would facilitate the identification of the full spectrum of physiological RIG-I ligands produced during IAV infection.
Copyright ? 2019 American Society for Microbiology.
PMID: 30760567 DOI: 10.1128/JVI.02299-18
[h=1]Cytoplasm and Beyond: The Dynamic Innate Immune Sensing of Influenza A Virus by RIG-I.[/h] Liu G[SUP]1[/SUP], Zhou Y[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Innate immune sensing of influenza A virus (IAV) requires RIG-I, a fundamental cytoplasmic RNA sensor. How RIG-I's cytoplasmic localization reconciles with the nuclear replication nature of IAV is poorly understood. Recent findings provide advanced insights into the spatiotemporal RIG-I sensing of IAV and highlight the contribution of various RNA ligands to RIG-I activation. Understanding a compartment-specific RIG-I sensing paradigm would facilitate the identification of the full spectrum of physiological RIG-I ligands produced during IAV infection.
Copyright ? 2019 American Society for Microbiology.
PMID: 30760567 DOI: 10.1128/JVI.02299-18