tetano
Editor, Senior Moderator
Diabetes Metab Res Rev. 2020 Mar 31:e33213321. doi: 10.1002/dmrr.3321. [Epub ahead of print]
Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics.
Maddaloni E[SUP]1[/SUP], Buzzetti R[SUP]1[/SUP].
Author information
Abstract
A novel RNA betacoronavirus causing coronavirus disease 2019 (Covid-19) has now been declared pandemic disease by WHO. Guo W et al published the first report of biochemical features in patients with diabetes and the further risk that this disease can determine to the progression of Covid-19. Among different cytokines found significantly higher in patients with diabetes compared to those without, Interleukin-6 (IL-6) which is already increased in conditions of chronic inflammation, may play a more deleterious role in Covid-19 infection. Targeting the over expression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Covid-19; Diabetes; Inflammation; IL-6
PMID:32233018DOI:10.1002/dmrr.3321
Covid-19 and diabetes mellitus: unveiling the interaction of two pandemics.
Maddaloni E[SUP]1[/SUP], Buzzetti R[SUP]1[/SUP].
Author information
Abstract
A novel RNA betacoronavirus causing coronavirus disease 2019 (Covid-19) has now been declared pandemic disease by WHO. Guo W et al published the first report of biochemical features in patients with diabetes and the further risk that this disease can determine to the progression of Covid-19. Among different cytokines found significantly higher in patients with diabetes compared to those without, Interleukin-6 (IL-6) which is already increased in conditions of chronic inflammation, may play a more deleterious role in Covid-19 infection. Targeting the over expression of Il-6 effects with a monoclonal antibody against IL-6 receptor or using Janus Kinase inhibitors may be particularly helpful for treatment of Covid-19 pneumonia in diabetes. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Covid-19; Diabetes; Inflammation; IL-6
PMID:32233018DOI:10.1002/dmrr.3321