tetano
Editor, Senior Moderator
Diabetes Metab Syndr. 2020 Apr 29;14(4):469-471. doi: 10.1016/j.dsx.2020.04.033. [Epub ahead of print]
SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects.
Michalakis K[SUP]1[/SUP], Ilias I[SUP]2[/SUP].
Author information
Abstract
BACKROUND AND AIMS:
According to the World Obesity Federation, "obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)"; additionally the Centres for Disease Control and Prevention reported that "people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness". Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.
METHODS:
Pubmed search on obesity and SARS-CoV-2 infection.
RESULTS:
We present "mechanistic" obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.
CONCLUSION:
Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.
Copyright ? 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Coronavirus; Glucose; Human; Infection; Inflammation; Obesity
PMID:32387864DOI:10.1016/j.dsx.2020.04.033
SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects.
Michalakis K[SUP]1[/SUP], Ilias I[SUP]2[/SUP].
Author information
Abstract
BACKROUND AND AIMS:
According to the World Obesity Federation, "obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)"; additionally the Centres for Disease Control and Prevention reported that "people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness". Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection.
METHODS:
Pubmed search on obesity and SARS-CoV-2 infection.
RESULTS:
We present "mechanistic" obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases.
CONCLUSION:
Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.
Copyright ? 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
Coronavirus; Glucose; Human; Infection; Inflammation; Obesity
PMID:32387864DOI:10.1016/j.dsx.2020.04.033