sharon sanders
Editor-in-Chief & President
Apparently researchers restored normal blood sugar metabolism in diabetic mice using a compound the body makes naturally.
The full article is free! :applause:
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
Cell Metabolism, Volume 14, Issue 4, 528-536, 5 October 2011
Authors:
Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai
All 3 from Washington University School of Medicine in St. Louis
Summary
snip
Here, we show that NAMPT-mediated NAD+ biosynthesis is severely compromised in metabolic organs by high-fat diet (HFD). Strikingly, nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice.
snip
These findings provide critical insights into a potential nutriceutical intervention against diet- and age-induced T2D.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00346-9
The full article is free! :applause:
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
Cell Metabolism, Volume 14, Issue 4, 528-536, 5 October 2011
Authors:
Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai
All 3 from Washington University School of Medicine in St. Louis
Summary
snip
Here, we show that NAMPT-mediated NAD+ biosynthesis is severely compromised in metabolic organs by high-fat diet (HFD). Strikingly, nicotinamide mononucleotide (NMN), a product of the NAMPT reaction and a key NAD+ intermediate, ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice.
snip
These findings provide critical insights into a potential nutriceutical intervention against diet- and age-induced T2D.
http://www.cell.com/cell-metabolism/abstract/S1550-4131(11)00346-9