tetano
Editor, Senior Moderator
Diagn Pathol
. 2021 Apr 13;16(1):31.
doi: 10.1186/s13000-021-01092-5.
Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
Amira Mohammed Ali[SUP] 1 2 [/SUP], Hiroshi Kunugi[SUP] 3 4 [/SUP]
Affiliations
Abstract
Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.
Keywords: *albumin*; Blood urea nitrogen; COVID-19; Coronavirus disease 2019; Disease severity; Hypoproteinemia; Intensive care unit; Malnutrition; Mortality; Multiple organ failure.
. 2021 Apr 13;16(1):31.
doi: 10.1186/s13000-021-01092-5.
Hypoproteinemia predicts disease severity and mortality in COVID-19: a call for action
Amira Mohammed Ali[SUP] 1 2 [/SUP], Hiroshi Kunugi[SUP] 3 4 [/SUP]
Affiliations
- PMID: 33849598
- DOI: 10.1186/s13000-021-01092-5
Abstract
Proteins represent the major building blocks of body tissues, and they regulate signaling involved in most cellular activities. Coronavirus disease 2019 (COVID-19) infection has been associated with high fatality, especially among older adults. The main cause of death is pulmonary tissue damage and multiple organ failure. The disease is associated with a hypercatabolic state that entails excessive protein loss. This review commentary sheds the light on hypoproteinemia in symptomatic/hospitalized COVID-19 with a special emphasis on its pathophysiology, screening, as well as its contribution to disease severity and adverse effects.
Keywords: *albumin*; Blood urea nitrogen; COVID-19; Coronavirus disease 2019; Disease severity; Hypoproteinemia; Intensive care unit; Malnutrition; Mortality; Multiple organ failure.