tetano
Editor, Senior Moderator
Diagnostics (Basel)
. 2021 Dec 28;12(1):57.
doi: 10.3390/diagnostics12010057.
Subclinical Myocardial Dysfunction in Patients with Persistent Dyspnea One Year after COVID-19
Maria-Luiza Luchian[SUP] 1 [/SUP], Andreea Motoc[SUP] 1 [/SUP], Stijn Lochy[SUP] 1 [/SUP], Julien Magne[SUP] 2 3 [/SUP], Dries Belsack[SUP] 4 [/SUP], Johan De Mey[SUP] 4 [/SUP], Bram Roosens[SUP] 1 [/SUP], Karen Van den Bussche[SUP] 1 [/SUP], Sven Boeckstaens[SUP] 1 [/SUP], Hadischat Chameleva[SUP] 5 [/SUP], Jolien Geers[SUP] 1 [/SUP], Laura Houard[SUP] 1 [/SUP], Tom De Potter[SUP] 5 [/SUP], Sabine Allard[SUP] 6 [/SUP], Caroline Weytjens[SUP] 1 [/SUP], Steven Droogmans[SUP] 1 [/SUP], Bernard Cosyns[SUP] 1 [/SUP]
Affiliations
Abstract
Long coronavirus disease 2019 (COVID-19) was described in patients recovering from COVID-19, with dyspnea being a frequent symptom. Data regarding the potential mechanisms of long COVID remain scarce. We investigated the presence of subclinical cardiac dysfunction, assessed by transthoracic echocardiography (TTE), in recovered COVID-19 patients with or without dyspnea, after exclusion of previous cardiopulmonary diseases. A total of 310 consecutive COVID-19 patients were prospectively included. Of those, 66 patients (mean age 51.3 ± 11.1 years, almost 60% males) without known cardiopulmonary diseases underwent one-year follow-up consisting of clinical evaluation, spirometry, chest computed tomography, and TTE. From there, 23 (34.8%) patients reported dyspnea. Left ventricle (LV) ejection fraction was not significantly different between patients with or without dyspnea (55.7 ± 4.6 versus (vs.) 57.6 ± 4.5, p = 0.131). Patients with dyspnea presented lower LV global longitudinal strain, global constructive work (GCW), and global work index (GWI) compared to asymptomatic patients (-19.9 ± 2.1 vs. -21.3 ± 2.3 p = 0.039; 2183.7 ± 487.9 vs. 2483.1 ± 422.4, p = 0.024; 1960.0 ± 396.2 vs. 2221.1 ± 407.9, p = 0.030). GCW and GWI were inversely and independently associated with dyspnea (p = 0.035, OR 0.998, 95% CI 0.997-1.000; p = 0.040, OR 0.998, 95% CI 0.997-1.000). Persistent dyspnea one-year after COVID-19 was present in more than a third of the recovered patients. GCW and GWI were the only echocardiographic parameters independently associated with symptoms, suggesting a decrease in myocardial performance and subclinical cardiac dysfunction.
Keywords: echocardiography; global longitudinal strain; long COVID-19; myocardial work; persistent dyspnea; subclinical dysfunction.
. 2021 Dec 28;12(1):57.
doi: 10.3390/diagnostics12010057.
Subclinical Myocardial Dysfunction in Patients with Persistent Dyspnea One Year after COVID-19
Maria-Luiza Luchian[SUP] 1 [/SUP], Andreea Motoc[SUP] 1 [/SUP], Stijn Lochy[SUP] 1 [/SUP], Julien Magne[SUP] 2 3 [/SUP], Dries Belsack[SUP] 4 [/SUP], Johan De Mey[SUP] 4 [/SUP], Bram Roosens[SUP] 1 [/SUP], Karen Van den Bussche[SUP] 1 [/SUP], Sven Boeckstaens[SUP] 1 [/SUP], Hadischat Chameleva[SUP] 5 [/SUP], Jolien Geers[SUP] 1 [/SUP], Laura Houard[SUP] 1 [/SUP], Tom De Potter[SUP] 5 [/SUP], Sabine Allard[SUP] 6 [/SUP], Caroline Weytjens[SUP] 1 [/SUP], Steven Droogmans[SUP] 1 [/SUP], Bernard Cosyns[SUP] 1 [/SUP]
Affiliations
- PMID: 35054224
- DOI: 10.3390/diagnostics12010057
Abstract
Long coronavirus disease 2019 (COVID-19) was described in patients recovering from COVID-19, with dyspnea being a frequent symptom. Data regarding the potential mechanisms of long COVID remain scarce. We investigated the presence of subclinical cardiac dysfunction, assessed by transthoracic echocardiography (TTE), in recovered COVID-19 patients with or without dyspnea, after exclusion of previous cardiopulmonary diseases. A total of 310 consecutive COVID-19 patients were prospectively included. Of those, 66 patients (mean age 51.3 ± 11.1 years, almost 60% males) without known cardiopulmonary diseases underwent one-year follow-up consisting of clinical evaluation, spirometry, chest computed tomography, and TTE. From there, 23 (34.8%) patients reported dyspnea. Left ventricle (LV) ejection fraction was not significantly different between patients with or without dyspnea (55.7 ± 4.6 versus (vs.) 57.6 ± 4.5, p = 0.131). Patients with dyspnea presented lower LV global longitudinal strain, global constructive work (GCW), and global work index (GWI) compared to asymptomatic patients (-19.9 ± 2.1 vs. -21.3 ± 2.3 p = 0.039; 2183.7 ± 487.9 vs. 2483.1 ± 422.4, p = 0.024; 1960.0 ± 396.2 vs. 2221.1 ± 407.9, p = 0.030). GCW and GWI were inversely and independently associated with dyspnea (p = 0.035, OR 0.998, 95% CI 0.997-1.000; p = 0.040, OR 0.998, 95% CI 0.997-1.000). Persistent dyspnea one-year after COVID-19 was present in more than a third of the recovered patients. GCW and GWI were the only echocardiographic parameters independently associated with symptoms, suggesting a decrease in myocardial performance and subclinical cardiac dysfunction.
Keywords: echocardiography; global longitudinal strain; long COVID-19; myocardial work; persistent dyspnea; subclinical dysfunction.