tetano
Editor, Senior Moderator
Influenza Other Respir Viruses. 2018 Aug 23. doi: 10.1111/irv.12606. [Epub ahead of print]
[h=1]Differential risk of hospitalization among single virus infections causing influenza like illnesses.[/h] Ortiz-Hern?ndez AA[SUP]1[/SUP], Nishimura KK[SUP]2[/SUP], Noyola DE[SUP]3[/SUP], Moreno-Espinosa S[SUP]4[/SUP], Gami?o A[SUP]4[/SUP], Galindo-Fraga A[SUP]5[/SUP], Vald?z V?zquez R[SUP]6[/SUP], Maga?a Aquino M[SUP]7[/SUP], Ramirez-Venegas A[SUP]8[/SUP], Vald?s Salgado R[SUP]9[/SUP], Andrade-Platas D[SUP]1[/SUP], Estevez-Jimen?z J[SUP]1[/SUP], Ruiz-Palacios GM[SUP]5[/SUP], Guerrero ML[SUP]5[/SUP], Beigel J[SUP]10[/SUP], Smolskis MC[SUP]2[/SUP], Hunsberger S[SUP]2[/SUP], Freimanis-Hence L[SUP]7[/SUP], Llamosas-Gallardo B[SUP]1[/SUP]; Mexico Emerging Infectious Diseases Clinical Research Network (La Red).
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Acute respiratory infections are a major cause of morbidity in children, and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza like illness (ILI).
[h=4]METHODS:[/h] Data from children 5 years old or younger participating in an ILI natural history study from April 2010 through March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (RSV), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus/enterovirus, coronavirus, adenovirus, and influenza.
[h=4]RESULTS:[/h] 1,486 children (408 outpatients and 1,078 inpatients) were included in this analysis. At least one virus was detected in 1,227 (82.6%) patients. The most frequent viruses detected as single pathogens were RSV (n=286), rhinovirus/enterovirus (n=251), parainfluenza viruses (n=104), and influenza A or B (n=99). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment and underlying illnesses), children with RSV and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (OR 2.7 and 1.9, respectively), rhinovirus/enterovirus (OR 3.1 and 2.1, respectively), coronaviruses (OR 4.9 and 3.4, respectively), adenovirus (OR 4.6 and 3.2, respectively), and influenza (OR 6.3 and 4.4, respectively).
[h=4]CONCLUSIONS:[/h] Children presenting with ILI caused by RSV and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 30137695 DOI: 10.1111/irv.12606
Free full text
[h=1]Differential risk of hospitalization among single virus infections causing influenza like illnesses.[/h] Ortiz-Hern?ndez AA[SUP]1[/SUP], Nishimura KK[SUP]2[/SUP], Noyola DE[SUP]3[/SUP], Moreno-Espinosa S[SUP]4[/SUP], Gami?o A[SUP]4[/SUP], Galindo-Fraga A[SUP]5[/SUP], Vald?z V?zquez R[SUP]6[/SUP], Maga?a Aquino M[SUP]7[/SUP], Ramirez-Venegas A[SUP]8[/SUP], Vald?s Salgado R[SUP]9[/SUP], Andrade-Platas D[SUP]1[/SUP], Estevez-Jimen?z J[SUP]1[/SUP], Ruiz-Palacios GM[SUP]5[/SUP], Guerrero ML[SUP]5[/SUP], Beigel J[SUP]10[/SUP], Smolskis MC[SUP]2[/SUP], Hunsberger S[SUP]2[/SUP], Freimanis-Hence L[SUP]7[/SUP], Llamosas-Gallardo B[SUP]1[/SUP]; Mexico Emerging Infectious Diseases Clinical Research Network (La Red).
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Acute respiratory infections are a major cause of morbidity in children, and are often caused by viruses. However, the relative severity of illness associated with different viruses is unclear. The objective of this study was to evaluate the risk of hospitalization from different viruses in children presenting with an influenza like illness (ILI).
[h=4]METHODS:[/h] Data from children 5 years old or younger participating in an ILI natural history study from April 2010 through March 2014 was analyzed. The adjusted odds ratio for hospitalization was estimated in children with infections caused by respiratory syncytial virus (RSV), metapneumovirus, bocavirus, parainfluenza viruses, rhinovirus/enterovirus, coronavirus, adenovirus, and influenza.
[h=4]RESULTS:[/h] 1,486 children (408 outpatients and 1,078 inpatients) were included in this analysis. At least one virus was detected in 1,227 (82.6%) patients. The most frequent viruses detected as single pathogens were RSV (n=286), rhinovirus/enterovirus (n=251), parainfluenza viruses (n=104), and influenza A or B (n=99). After controlling for potential confounders (age, sex, recruitment site, days from symptom onset to enrollment and underlying illnesses), children with RSV and metapneumovirus infections showed a greater likelihood of hospitalization than those infected by parainfluenza viruses (OR 2.7 and 1.9, respectively), rhinovirus/enterovirus (OR 3.1 and 2.1, respectively), coronaviruses (OR 4.9 and 3.4, respectively), adenovirus (OR 4.6 and 3.2, respectively), and influenza (OR 6.3 and 4.4, respectively).
[h=4]CONCLUSIONS:[/h] Children presenting with ILI caused by RSV and metapneumovirus were at greatest risk for hospitalization, while children with rhinovirus/enterovirus, parainfluenza, coronavirus, adenovirus, and influenza were at lower risk of hospitalization. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
PMID: 30137695 DOI: 10.1111/irv.12606
Free full text