tetano
Editor, Senior Moderator
Virus Res. 2014 Mar 21. pii: S0168-1702(14)00117-8. doi: 10.1016/j.virusres.2014.03.010. [Epub ahead of print]
Downregulation of Angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Liu X1, Yang N2, Tang J3, Liu S3, Luo D4, Duan Q4, Wang X4.
Author information
Abstract
Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed that ACE2 protein levels were significantly downregulated after infection with H1N1 viruses but was dispensable for viral replication. ACE2 protein downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than ACE2 shedding. Finally, we found that ACE2 cleavage could be regulated by influenza neuraminidase (NA), which was fundamentally different from the classically sheddase-induced proteolytic cleavage of ACE2.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
ACE2, Downregulation, Influenza, Neuraminidase
PMID:
24662240
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24662240
Downregulation of Angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Liu X1, Yang N2, Tang J3, Liu S3, Luo D4, Duan Q4, Wang X4.
Author information
Abstract
Influenza A (H1N1) virus, a high-risk infectious pathogen, can cause severe acute lung injury leading to significant morbidity and mortality. Angiotensin-converting enzyme 2 (ACE2), a negative regulator of the renin-angiotensin system (RAS), plays a protective role in pathogenesis of acute lung injury. Here, we showed that ACE2 protein levels were significantly downregulated after infection with H1N1 viruses but was dispensable for viral replication. ACE2 protein downregulation was most likely related to ACE2 protein degradation by proteasome pathway rather than ACE2 shedding. Finally, we found that ACE2 cleavage could be regulated by influenza neuraminidase (NA), which was fundamentally different from the classically sheddase-induced proteolytic cleavage of ACE2.
Copyright ? 2014 Elsevier B.V. All rights reserved.
KEYWORDS:
ACE2, Downregulation, Influenza, Neuraminidase
PMID:
24662240
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24662240